Search Results - assembly

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Mouse Monoclonal Antibodies to MAD1, a Human Spindle Assembly Checkpoint Protein for Maintaining Chromosomal Segregation

Scientists at the National Institutes of Health have developed mouse monoclonal antibodies against the human spindle assembly checkpoint protein, MAD1. The spindle assembly checkpoint in mitotic cell division regulates the fidelity of chromosome segregation during cell division. MAD1 is an important component of this checkpoint control, which if compromised,...

Published: 7/25/2024 | Inventor(s): Kuan-teh Jeang (Estate)

Keywords(s): (4)r syndrome, Against, ANEUPLOIDY, antibodies, ASSEMBLY, C syndrome, CAXXXX, CC2XXX, CCXXXX, CHECKPOINT, Chromosome 4 ring syndrome, Chromosome 6 ring syndrome, Chromosome 7 ring syndrome, CXXXXX, G syndrome, Human, Hypertelorism with esophageal abnormality and hypospadias, MAD1, monoclonal, Mouse, N syndrome, Protein, R(6) syndrome, R(7) syndrome, spindle, Syndrome X, W syndrome, W syndrome; Syndrome W

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Diagnostics, Application > Research Materials

Amelioration of Inflammatory Arthritis Targeting the Pre-ligand Assembly Domain (PLAD) of Tumor Necrosis Factor Receptors

The invention relates to compositions of matter and methods for treating arthritis by modulating Tumor Necrosis Factor Alpha (TNF-alpha) signaling. TNF-alpha plays a key role in the pathogenesis of numerous diseases including rheumatoid and septic arthritis, and other autoimmune and inflammatory diseases. TNF-alpha mediates its effects through receptors...

Published: 7/25/2024 | Inventor(s): Michael Lenardo, Francis Chan, Richard Siegel

Keywords(s): ASSEMBLY, BCXXXX, CB3AXX, CBXXXX, CC1XXX, CCXXXX, CXXXXX, Domain, factor, FAMILY, FUNCTION., Identification, Listed LPM Hastings as of 4/15/2015, Mediates, NECROSIS, Novel, Patent Category - Biotechnology, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, PRE-LIGAND, RECEPTOR, SACGHS DNA Patent Initial Set, That, tumor

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Oncology