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Amelioration of Inflammatory Arthritis Targeting the Pre-ligand Assembly Domain (PLAD) of Tumor Necrosis Factor Receptors
Case ID:
TAB-1204
Web Published:
12/6/2022
Description:
The invention relates to compositions of matter and methods for treating arthritis by modulating Tumor Necrosis Factor Alpha (TNF-alpha) signaling. TNF-alpha plays a key role in the pathogenesis of numerous diseases including rheumatoid and septic arthritis, and other autoimmune and inflammatory diseases. TNF-alpha mediates its effects through receptors that contain a Pre-ligand Assembly Domain (PLAD). The inventors have discovered compounds that interfere with PLAD can block the effects of TNF-alpha in vitro. Treatment of mice with these compounds in vivo ameliorated disease in several models of arthritis. Therefore, the compositions and methods of the current invention may lead to novel arthritis treatments.
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Direct Link:
https://nih.technologypublisher.com/tech/Amelioration_of_Inflammatory_Arthrit is_Targeting_the_Pre-ligand_Assembly_Domain_(PLAD)_of_Tumor_Necrosis_Factor_Receptors
Category(s):
Licensing
Research Materials
Therapeutics
Oncology
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For Information, Contact:
Yogikala Prabhu
Technology Transfer Patent Specialist
NIH Technology Transfer
+1 240 276 5530
yogikala.prabhu@nih.gov
Inventors:
Michael Lenardo
Francis Chan
Richard Siegel
Keywords:
ASSEMBLY
BCXXXX
CB3AXX
CBXXXX
CC1XXX
CCXXXX
CXXXXX
Domain
factor
FAMILY
FUNCTION.
Identification
Listed LPM Hastings as of 4/15/2015
Mediates
NECROSIS
Novel
Patent Category - Biotechnology
Post LPM Assignment Set 20150420
Pre LPM working set 20150418
PRE-LIGAND
RECEPTOR
SACGHS DNA Patent Initial Set
That
tumor
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