Search Results - cc1xxx

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A plasmid encodes human interleukin-8 (IL-8) receptor CXCR1. IL-8 is a chemo-attractant cytokine that attracts and activates neutrophils in inflammatory regions.

Published: 10/28/2024 | Inventor(s): Sunil Ahuja, Philip Murphy

Keywords(s): CB3AXX, CC1XXX, cDNA, CXCRI, Hu, Human, IL-8, IL-8A, Listed LPM Ano as of 4/15/2015, PLASMID, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RECEPTOR, RM, Subtype, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology, Application > Research Materials

A Mouse Model of Multiple Endocrine Neoplasia, Type I

The current invention embodies a mouse model which is heterozygous for a null allele at the Men1 locus of murine chromosome 19. Men1 has similar exon-intron organization and amino acid identity compared with its human analog MEN1, which has been implicated in the pathogenesis of multiple endocrine neoplasia, type I (MENI). This mouse model has been...

Published: 8/12/2024 | Inventor(s): Judy Crabtree, Francis Collins

Keywords(s): CC1XXX, CC3XXX, CCXXXX, CXXXXX, endocrine, GB1A3X, GB1AXX, GB1XXX, GB2BXX, GB2XXX, GBXXXX, GCXXXX, GXXXXX, Men1 locus, Model, Mouse, mouse model, MULTIPLE, Multiple endocrine neoplasia, Multiple endocrine neoplasia type 1, Multiple endocrine neoplasia, type 2, murine chromosome 19, NEOPLASIA, tumor formation, TYPE, Zollinger-Ellison syndrome

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Oncology

Amelioration of Inflammatory Arthritis Targeting the Pre-ligand Assembly Domain (PLAD) of Tumor Necrosis Factor Receptors

The invention relates to compositions of matter and methods for treating arthritis by modulating Tumor Necrosis Factor Alpha (TNF-alpha) signaling. TNF-alpha plays a key role in the pathogenesis of numerous diseases including rheumatoid and septic arthritis, and other autoimmune and inflammatory diseases. TNF-alpha mediates its effects through receptors...

Published: 10/28/2024 | Inventor(s): Michael Lenardo, Francis Chan, Richard Siegel

Keywords(s): ASSEMBLY, BCXXXX, CB3AXX, CBXXXX, CC1XXX, CCXXXX, CXXXXX, Domain, factor, FAMILY, FUNCTION., Identification, Listed LPM Hastings as of 4/15/2015, Mediates, NECROSIS, Novel, Patent Category - Biotechnology, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, PRE-LIGAND, RECEPTOR, SACGHS DNA Patent Initial Set, That, tumor

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Oncology