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Search Results - gb2bxx
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Compositions for Modification of Genomic DNA and Exogenous Gene Expression
A novel method of targeted insertion of transgenes at CLYBL locus directly in human cells is disclosed. Also, methods and compositions for increasing targeted insertion of a transgene into a specific location within the cell or increasing the frequency of gene modification in a targeted locus are disclosed. Genome modification by precise gene targeting...
Published: 7/30/2024
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Inventor(s):
Mahendra Rao
,
Jizhong Zou
Keywords(s):
Cl
,
Compositions
,
GB2BXX
,
GB2CXX
,
Genome
,
Harbor
,
LOCUS
,
Methods
,
MODIFICATION
,
SAFE
,
Targeted
,
VEXXXX
,
WIXXXX
,
WJXXXX
,
XEXXXX
,
YAXXXX
,
YBL
,
YBXXXX
Category(s):
Collaboration Sought > Licensing
,
Application > Research Materials
,
Application > Therapeutics
,
TherapeuticArea > Neurology
A Mouse Model of Multiple Endocrine Neoplasia, Type I
The current invention embodies a mouse model which is heterozygous for a null allele at the Men1 locus of murine chromosome 19. Men1 has similar exon-intron organization and amino acid identity compared with its human analog MEN1, which has been implicated in the pathogenesis of multiple endocrine neoplasia, type I (MENI). This mouse model has been...
Published: 8/12/2024
|
Inventor(s):
Judy Crabtree
,
Francis Collins
Keywords(s):
CC1XXX
,
CC3XXX
,
CCXXXX
,
CXXXXX
,
endocrine
,
GB1A3X
,
GB1AXX
,
GB1XXX
,
GB2BXX
,
GB2XXX
,
GBXXXX
,
GCXXXX
,
GXXXXX
,
Men1 locus
,
Model
,
Mouse
,
mouse model
,
MULTIPLE
,
Multiple endocrine neoplasia
,
Multiple endocrine neoplasia type 1
,
Multiple endocrine neoplasia, type 2
,
murine chromosome 19
,
NEOPLASIA
,
tumor formation
,
TYPE
,
Zollinger-Ellison syndrome
Category(s):
Collaboration Sought > Licensing
,
Application > Research Materials
,
Application > Therapeutics
,
TherapeuticArea > Oncology
Methods and Materials for Controlling Stem Cell and Cancer Cell Proliferation and Differentiation
This work describes a novel nucleolar mechanism that controls the cell-cycle progression in CNS stem cells and cancer cells. The inventors identified a novel peptide, nucleostemin, found in the nucleoli of CNS stem cells, embryonic stem cells, and several cancer cell lines and preferentially expressed by other stem cell-enriched populations. When...
Published: 4/8/2024
|
Inventor(s):
Robert Tsai
,
Ronald McKay
Keywords(s):
CB2BXX
,
CBXXXX
,
CXXXXX
,
GB2BXX
,
GBXXXX
,
GXXXXX
,
IBXXXX
,
IXXXXX
Category(s):
Collaboration Sought > Licensing
,
Application > Diagnostics
,
Application > Research Materials
,
TherapeuticArea > Oncology
,
Application > Therapeutics
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