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Neutralizing Monoclonal Antibodies Against West Nile Virus

West Nile virus (WNV) is a mosquito-borne flavivirus that can cause fever and, in some cases, severe neurologic disease. There is no approved human vaccine or specific antiviral treatment for WNV. Researchers at NIAID's Vaccine Research Center (VRC), working with collaborators at Sheba Medical Center under the PREMISE program, identified...

Published: 4/24/2026 | Updated: 4/24/2026 | Inventor(s): Daniel Douek, Chaim Schramm, Ananda Chowdhury, Parker Dabbs, Lu Wang, Leonid Serebryannyy, Theodore Pierson, Kimberly Dowd, Laura Vanblargan, Katherine Burgomaster, David Gordon, Yuxiang Wang, Yaniv Lustig, Yael Ottolenghi, Dror Harats, Sarah Smith (Kerscher)

Keywords(s):

Category(s): Application, ResearchProducts > Virus/Bacteria, ResearchProducts, ResearchProducts > Antibodies, TherapeuticArea, Application > Diagnostics

Neutralizing Antibodies Against West Nile Virus

West Nile virus (WNV) is a mosquito-borne virus that can cause severe disease affecting the brain and nervous system, especially in older adults and people with weakened immune systems. There is no approved human vaccine or specific antiviral treatment for WNV. Researchers at NIAID’s Vaccine Research Center (VRC), together with collaborators...

Published: 4/23/2026 | Updated: 4/22/2026 | Inventor(s): Theodore Pierson, Kimberly Dowd, Daniel Douek, Dror Harats, Yael Ottolenghi, Gili Regev-Yochay, Yaniv Lustig

Keywords(s):

Category(s): TherapeuticArea, Application > Vaccines, Application, Application > Diagnostics, ResearchProducts, ResearchProducts > Virus/Bacteria

Methods To Regulate Metabolism For Treatment Of Neural Injuries and Neurodegeneration

Description of Technology: Axonal injury and subsequent neuronal death underpin the pathology of many neurological disorders from acute neural injuries (motor vehicle crashes, combat related injuries, traumatic brain injuries) to neurological diseases (multiple sclerosis, glaucoma). In the central nervous system (CNS), microglia help respond to CNS...

Published: 4/16/2026 | Updated: 4/16/2026 | Inventor(s): Wei Li, Jingxing Ou, Tantai Zhao

Keywords(s):

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Ear, Nose, & Throat, TherapeuticArea > Neurology, Collaboration Sought > Licensing

DNA Methylation-Based Cancer Diagnostics for Accurate Tumor Classification

Summary: The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a collection of T-cell receptors (TCRs) that specifically target the mutated KRAS antigen. This technology encompasses a DNA methylation–based diagnostic platform designed to improve the accuracy and consistency of cancer classification,...

Published: 4/23/2026 | Updated: 4/10/2026 | Inventor(s): Kenneth Aldape, Ziedulla Abdullaev, Rustamzhon Turakulov, Stefania Pittaluga, Mark Raffeld, Elaine Jaffe, Omkar Singh, Antonios Papanicolau-Sengos

Keywords(s):

Category(s): Application > Diagnostics, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing

Nucleophosmin 1 (NPM1) Mutation-Specific T Cell Receptors for Targeted Treatment of Acute Myeloid Leukemia

Summary: The NCI seeks research co-development partners or licensees for Nucleophosmin 1 (NPM1) Mutation-Specific T Cell Receptors for Targeted Treatment of Acute Myeloid Leukemia. Description of Technology: Acute myeloid leukemia (AML) is a rare form of blood cancer affecting myeloid stem and progenitor cells, associated with a poor prognosis...

Published: 4/10/2026 | Updated: 4/10/2026 | Inventor(s): Vid Leko, Aidan Pursley, Kenichi Hanada, Zhiya Yu, Catherine Ade, James Yang

Keywords(s):

Category(s): Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing

48-Position Custom Deep Well Plate For In Vitro Equilibrium Dialysis at a 1:1 Sample to Buffer Volume Ratio

CDC scientists have developed a new design for a multi-well dialysis microplate for equilibrium dialysis. The unique design accommodates a 1:1 buffer to sample ratio and provides additional room at the base of the well to enable optimal cartridge immersion and analyte diffusion. The microplate is readily adaptable into existing automated analytical...

Published: 4/10/2026 | Updated: 4/8/2026 | Inventor(s): Ashley Ribera, Hui Zhou, Hubert Vesper

Keywords(s):

Category(s): Application > Diagnostics, Application > Research Materials, Collaboration Sought, TherapeuticArea, TherapeuticArea > Endocrinology, TherapeuticArea > Geriatrics, TherapeuticArea > Hematology, TherapeuticArea > Obstetrics/Neo-Natal, TherapeuticArea > Reproductive Health, TherapeuticArea > Urology

Novel malaria vaccine candidates comprising engineered nanoparticles

Using proteins derived from the malaria Plasmodium falciparum parasite, NIAID has developed three different nanoparticle platforms to serve as scaffolds for displaying multiple copies of malaria antigens in an organized, repetitive manner to enhance vaccine effectiveness. The first platform uses the pyridoxal 5’-phosphate (PLP) synthase protein...

Published: 3/23/2026 | Updated: 3/23/2026 | Inventor(s): Niraj Tolia, Dashuang Shi, Vu Nguyen, Thayne Dickey

Keywords(s):

Category(s): TherapeuticArea, ResearchProducts, Collaboration Sought, Application > Vaccines

Gene Editing for ALPK1 p.Thr237Met

ROSAH syndrome is a rare genetic disease caused by a mutation in the human alpha kinase 1 (ALPK1) gene (p.Thr237Met), leading to vision loss, swollen optic nerves, dry mouth, enlarged spleen, and frequent headaches. Researchers in the Laboratory of Clinical Immunology and Microbiology (LCIM) at the National Institute of Allergy and Infectious Diseases...

Published: 3/26/2026 | Updated: 3/23/2026 | Inventor(s): Christina Kozycki, Colin Sweeney, Uimook Choi

Keywords(s):

Category(s): Application, Collaboration Sought, ResearchProducts, TherapeuticArea, TherapeuticArea > Rare/Neglected Diseases

Pigment Epithelium-Derived Factor Peptides and Their Use for Treating Retinal Degeneration

Summary: The National Eye Institute (NEI) seeks research co-development partners and/or licensees for the development of an AAV2-based delivery system or an eyedrop formulation to deliver a Pigment Epithelium-Derived Factor (PEDF) peptide as a gene-agnostic approach to treating inherited retinal diseases. Description of Technology: Retinitis...

Published: 3/24/2026 | Updated: 3/13/2026 | Inventor(s): S. Patricia Becerra, Alexandra Bernardo-Colon, Valeria Marigo, Andrea Bighinati

Keywords(s):

Category(s): Application > Therapeutics, TherapeuticArea > Ear, Nose, & Throat, TherapeuticArea > Ophthalmology, Collaboration Sought > Licensing, Collaboration Sought > Collaboration

Systems and Methods to Automatically Detect Ellipsoid Zone Loss in SD-OCT Imaging

Summary: The National Eye Institute (NEI) seeks research co-development partners and/or licensees for an automatic deep learning-based algorithm to detect and quantitate ellipsoid zone (EZ) loss in Spectral Domain Optical Coherence Tomography (SD-OCT) images. Description of Technology: The present disclosure generally relates a method of automatically...

Published: 4/23/2026 | Updated: 3/11/2026 | Inventor(s): Wathudurage De Silva, Catherine Cukras

Keywords(s):

Category(s): Application > Software / Apps, TherapeuticArea, TherapeuticArea > Ear, Nose, & Throat, Collaboration Sought > Collaboration, Collaboration Sought > Licensing

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