Search Results - kapil+bharti

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Tissue Clamp for Repeated Opening and Closure of Incisions/Wounds

Abstract: Medical clamps currently available are not efficient nor are they sufficiently precise in closure and alignment of the edges of an incision or wound. Many available designs are difficult to use and handle, especially in situations where repeated opening and closure of an incision or wound is required. The functional short-comings of existing...

Published: 4/8/2024 | Inventor(s): Vladimir Khristov, Steven Charles, Juan Amaral, Arvydas Maminishkis, Kapil Bharti

Keywords(s): CLAMP, ocular surgery, sclera incision closure

Category(s): Collaboration Sought > Collaboration, Application > Non-Medical Devices, Application > Medical Devices, Collaboration Sought > Licensing, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat

3D Vascularized Human Ocular Tissue for Cell Therapy and Drug Discovery

Abstract: Degeneration of retinal tissues occurs in many ocular disorders resulting in the loss of vision. Dysfunction and/or loss of Retinal Pigment Epithelium Cells (RPE) and disruption of the associated blood retinal barrier (BRB) tissue structures are linked with many ocular diseases and conditions including: age-related macular degeneration (AMD),...

Published: 4/8/2024 | Inventor(s): Kapil Bharti, Min Jae Song, Russell Quinn

Keywords(s): 3D bio-printing, Bharti, Blood Retinal Barrier Disorder, BRB, Cell therapy, in Vitro Human Blood Retinal Barrier Model, Ocular cell therapy scaffold, Retinal disorder, Retinal Pigment Epithelium Cells

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, Application > Therapeutics

Devices for Improved Tissue Cryopreservation and Recovery

Abstract: Problem: Cryopreservation is a process where living biological materials like cells, tissues, and cell therapies (which are susceptible to damage caused by unregulated chemical kinetics) are preserved by cooling to very low temperatures in the presence of specific cryopreservation media that protects the biological material from damage. In...

Published: 4/8/2024 | Inventor(s): Vladimir Khristov, Arvydas Maminishkis, Kapil Bharti

Keywords(s): Cell recovery, Cell thawing, Cell therapy, Cryopreservation, Defrost, National Eye Institute, NEI, Tissue transplant

Category(s): Collaboration Sought > Materials Available, Application > Medical Devices, TherapeuticArea > Immunology, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, TherapeuticArea > Dermatology, Collaboration Sought > Licensing, Application > Non-Medical Devices, TherapeuticArea > Oncology, Collaboration Sought > Collaboration

Machine Learning and/or Neural Networks to Validate Stem Cells and Their Derivatives for Use in Cell Therapy, Drug Delivery, and Diagnostics

Abstract: Many biological and clinical procedures require functional validation of a desired cell type. Current techniques to validate rely on various assays and methods, such as staining with dyes, antibodies, and nucleic acid probes, to assess stem cell health, death, proliferation, and functionality. These techniques potentially destroy stem cells...

Published: 4/8/2024 | Inventor(s): Kapil Bharti, Nicholas Schaub, Carl Simon, Nathan Hotaling

Keywords(s): Bharti, Cell therapy, Cell Validation, Less Invasive Diagnostics, Machine Learning, Neural Networks, QUALITY CONTROL, Stem Cell Diagnostics, Stem Cell Therapy

Category(s): TherapeuticArea > Cardiology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Software / Apps, TherapeuticArea > Dermatology

Method for Reproducible Differentiation of Clinical Grade Retinal Pigment Epithelium Cells

Abstract: The retinal pigment epithelium (RPE) is a cell monolayer with specialized functions crucial to maintaining the metabolic environment and chemistry of the sub-retinal and choroidal layers in the eye. Damage or disease causing RPE cell loss leads to progressive photoreceptor damage and impaired vision. Loss of RPE is observed in many of the...

Published: 4/8/2024 | Inventor(s): Kapil Bharti

Keywords(s): Age Related Macular Degeneration, AMD, Best Disease, Bharti, Human Induced Pluripotent Stem Cells, Human Retinal Pigment Epithelial Cells, IPSCS, National Eye Institute, National Institute of Arthritis and Muscoskeletal and Skin D, NEI, NIAMS, Photoreceptor, Retinal Degenerative Diseases, RPE, STEM CELLS, Vision Loss

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, Collaboration Sought > Licensing

Metformin for the Treatment of Age-related Retinal Degeneration

Abstract: Retinal Degenerations (RD) are the leading cause of blindness in the United States. The degeneration of the Retinal Pigment Epithelium (RPE) is associated with various types of RD such as Stargardt’s disease, retinitis pigmentosa, choroideremia, Late-Onset Retinal Degeneration (L-ORD), and Age-related Macular Degeneration (AMD). The RPE as...

Published: 4/8/2024 | Inventor(s): Kapil Bharti, Kiyoharu Miyagishima, Fnu Ruchi, Justin Chang, Balendu Jha, Karla Barbosa-Sabenero, Katharina Clore-Gronenborn

Keywords(s): Age-related Macular Degeneration, AMD, Bharti, choroideremia, iPS cells, Late-Onset Retinal Degeneration, L-ORD, Metformin, RD, Retinal degeneration, Retinal Pigment Epithelium, Retinitis Pigmentosa, RPE, Stargardt’s disease

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat

Novel Methods for Generating Retinal Pigment Epithelium Cells from Induced Pluripotent Stem Cells

Abstract: The retinal pigment epithelial cells (RPE) make up a polarized monolayer in the vertebrate eye that separates the neural retina from the choroid, and performs a crucial role in retinal physiology by forming a blood-retinal barrier and closely interacting with photoreceptors to maintain visual function. Many ophthalmic diseases, such as age-related...

Published: 4/8/2024 | Inventor(s): Kapil Bharti, Kapil Bharti, Janine Davis, Sheldon Miller, Arvydas Maminishkis, Marc Ferrer-Alegre

Keywords(s): Age-related Macular Degeneration, AMD, DIFFERENTIATION, retinal pigment epithelial cells, STEM CELLS

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Collaboration Sought > Collaboration, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat

Novel Methods for Generating Retinal Pigment Epithelium Cells from Induced Pluripotent Stem Cells

Published: 4/8/2024 | Inventor(s): Kapil Bharti, Kapil Bharti, Janine Davis, Sheldon Miller, Arvydas Maminishkis, Marc Ferrer-Alegre

Keywords(s): Age-related Macular Degeneration, AMD, DIFFERENTIATION, retinal pigment epithelial cells, STEM CELLS

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Collaboration Sought > Collaboration, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat

Plasmid Useful in Transplantation Therapy for Age-Related Eye Disease

Researchers have developed a green fluorescent protein (GFP) based plasmid that can be used to detect differentiated retinal pigment epithelium (RPE) cells. RPE is a layer of cells located behind the eye that becomes damaged in age-related macular degeneration (AMD). Current cell based therapies for treating AMD focus on generating RPE cells from...

Published: 4/8/2024 | Inventor(s): Kapil Bharti

Keywords(s): Cell, CONSTRUCT, Generating, GFP-based, IBXXXX, IDXXXX, IXXXXX, Lines, REPORTER, RPE-specific, Stem

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics