Search Results - cell+therapy

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Induced Pluripotent Stem Cells Derived from Patients with CEP290-associated Ciliopathies and Unaffected Family Members

Abstract: Approximately one-third of non-syndromic retinal dystrophies involve a defect in a ciliary protein. Non-syndromic retinal ciliopathies include retinitis pigmentosa, cone dystrophy, cone-rod dystrophy, macular dystrophy, and Leber-congenital amaurosis (LCA). Many CEP290-LCA patients also exhibit auditory and olfactory defects. Induced pluripotent...

Published: 4/8/2024 | Inventor(s): Anand Swaroop, Hiroko Shimada-Ishii, Yu Holly Chen, Milton English

Keywords(s): Anosmia, Cell therapy, Ciliopathies, Congenital Blindness, Drug Development, GENE THERAPY, hearing loss, iPS, National Eye Institute, NEI, Pluripotent Stem Cells, Primary Cilia, Retina, Retinal degeneration, Swaroop, VISION

Category(s): Application > Research Materials, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat

3D Vascularized Human Ocular Tissue for Cell Therapy and Drug Discovery

Abstract: Degeneration of retinal tissues occurs in many ocular disorders resulting in the loss of vision. Dysfunction and/or loss of Retinal Pigment Epithelium Cells (RPE) and disruption of the associated blood retinal barrier (BRB) tissue structures are linked with many ocular diseases and conditions including: age-related macular degeneration (AMD),...

Published: 4/8/2024 | Inventor(s): Kapil Bharti, Min Jae Song, Russell Quinn

Keywords(s): 3D bio-printing, Bharti, Blood Retinal Barrier Disorder, BRB, Cell therapy, in Vitro Human Blood Retinal Barrier Model, Ocular cell therapy scaffold, Retinal disorder, Retinal Pigment Epithelium Cells

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, Application > Therapeutics

Devices for Improved Tissue Cryopreservation and Recovery

Abstract: Problem: Cryopreservation is a process where living biological materials like cells, tissues, and cell therapies (which are susceptible to damage caused by unregulated chemical kinetics) are preserved by cooling to very low temperatures in the presence of specific cryopreservation media that protects the biological material from damage. In...

Published: 4/8/2024 | Inventor(s): Vladimir Khristov, Arvydas Maminishkis, Kapil Bharti

Keywords(s): Cell recovery, Cell thawing, Cell therapy, Cryopreservation, Defrost, National Eye Institute, NEI, Tissue transplant

Category(s): Collaboration Sought > Materials Available, Application > Medical Devices, TherapeuticArea > Immunology, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, TherapeuticArea > Dermatology, Collaboration Sought > Licensing, Application > Non-Medical Devices, TherapeuticArea > Oncology, Collaboration Sought > Collaboration

Machine Learning and/or Neural Networks to Validate Stem Cells and Their Derivatives for Use in Cell Therapy, Drug Delivery, and Diagnostics

Abstract: Many biological and clinical procedures require functional validation of a desired cell type. Current techniques to validate rely on various assays and methods, such as staining with dyes, antibodies, and nucleic acid probes, to assess stem cell health, death, proliferation, and functionality. These techniques potentially destroy stem cells...

Published: 4/8/2024 | Inventor(s): Kapil Bharti, Nicholas Schaub, Carl Simon, Nathan Hotaling

Keywords(s): Bharti, Cell therapy, Cell Validation, Less Invasive Diagnostics, Machine Learning, Neural Networks, QUALITY CONTROL, Stem Cell Diagnostics, Stem Cell Therapy

Category(s): TherapeuticArea > Cardiology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Software / Apps, TherapeuticArea > Dermatology