Search Results - amd

5 Results

Sort By:

Method for Reproducible Differentiation of Clinical Grade Retinal Pigment Epithelium Cells

Abstract: The retinal pigment epithelium (RPE) is a cell monolayer with specialized functions crucial to maintaining the metabolic environment and chemistry of the sub-retinal and choroidal layers in the eye. Damage or disease causing RPE cell loss leads to progressive photoreceptor damage and impaired vision. Loss of RPE is observed in many of the...

Published: 4/8/2024 | Inventor(s): Kapil Bharti

Keywords(s): Age Related Macular Degeneration, AMD, Best Disease, Bharti, Human Induced Pluripotent Stem Cells, Human Retinal Pigment Epithelial Cells, IPSCS, National Eye Institute, National Institute of Arthritis and Muscoskeletal and Skin D, NEI, NIAMS, Photoreceptor, Retinal Degenerative Diseases, RPE, STEM CELLS, Vision Loss

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, Collaboration Sought > Licensing

Metformin for the Treatment of Age-related Retinal Degeneration

Abstract: Retinal Degenerations (RD) are the leading cause of blindness in the United States. The degeneration of the Retinal Pigment Epithelium (RPE) is associated with various types of RD such as Stargardt’s disease, retinitis pigmentosa, choroideremia, Late-Onset Retinal Degeneration (L-ORD), and Age-related Macular Degeneration (AMD). The RPE as...

Published: 4/8/2024 | Inventor(s): Kapil Bharti, Kiyoharu Miyagishima, Fnu Ruchi, Justin Chang, Balendu Jha, Karla Barbosa-Sabenero, Katharina Clore-Gronenborn

Keywords(s): Age-related Macular Degeneration, AMD, Bharti, choroideremia, iPS cells, Late-Onset Retinal Degeneration, L-ORD, Metformin, RD, Retinal degeneration, Retinal Pigment Epithelium, Retinitis Pigmentosa, RPE, Stargardt’s disease

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat

Selective estrogen-receptor modulators (SERMs) confer protection against photoreceptor degeneration

Abstract: Retinal degeneration is a deteriorative condition of the human retina caused by the progressive and eventual death of photoreceptor cells. To date, no effective treatment for genetically inherited or age-associated retinal degeneration, which includes a large patient population worldwide, is available. Researchers at the National Eye Institute...

Published: 4/8/2024 | Inventor(s): Wai Wong, Lian Zhao, Xu Wang, Wenxin Ma

Keywords(s): Age-Related Degeneration, AMD, Estrogen-receptor, Microglial Inhibition, National Eye Institute, NEI, Photoreceptor, Retinal degeneration, Retinitis Pigmentosa, RP

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, Collaboration Sought > Collaboration

Novel Methods for Generating Retinal Pigment Epithelium Cells from Induced Pluripotent Stem Cells

Abstract: The retinal pigment epithelial cells (RPE) make up a polarized monolayer in the vertebrate eye that separates the neural retina from the choroid, and performs a crucial role in retinal physiology by forming a blood-retinal barrier and closely interacting with photoreceptors to maintain visual function. Many ophthalmic diseases, such as age-related...

Published: 4/8/2024 | Inventor(s): Kapil Bharti, Kapil Bharti, Janine Davis, Sheldon Miller, Arvydas Maminishkis, Marc Ferrer-Alegre

Keywords(s): Age-related Macular Degeneration, AMD, DIFFERENTIATION, retinal pigment epithelial cells, STEM CELLS

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Collaboration Sought > Collaboration, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat

Murine Cell Models for Metastatic Squamous Cell Carcinoma

Two cell lines isolated from Pam 212 cells (SCC): Pam LY (lymph node metastasis) and Pam LU (lung metastasis) from metastated in vivo growth in mouse. These stably established cell lines exhibited higher potential to metastasize to lymph nodes and lungs, respectively, in mouse models than their parental Pam 212 cells.

Published: 7/25/2024 | Inventor(s): Carter Van Waes, Zhong Chen

Keywords(s): AMD, BUT, CCXXXX, Establish, Including, Limit, Lines, LU, LU1, LY, LY-1, LY-2, LY-8, Pam, VCXXXX, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology