Search Results - lian+zhao

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Selective estrogen-receptor modulators (SERMs) confer protection against photoreceptor degeneration

Abstract: Retinal degeneration is a deteriorative condition of the human retina caused by the progressive and eventual death of photoreceptor cells. To date, no effective treatment for genetically inherited or age-associated retinal degeneration, which includes a large patient population worldwide, is available. Researchers at the National Eye Institute...

Published: 12/6/2024 | Inventor(s): Wai Wong, Lian Zhao, Xu Wang, Wenxin Ma

Keywords(s): Age-Related Degeneration, AMD, Estrogen-receptor, Microglial Inhibition, National Eye Institute, NEI, Photoreceptor, Retinal degeneration, Retinitis Pigmentosa, RP

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Ear, Nose, & Throat, TherapeuticArea > Ophthalmology

Repurposed Use of the Alkaloids Emetine and Cephaeline to Treat Zika Virus Infection

This technology includes the use of two related compounds, Emetine and Cephaeline, as a potent inhibitor of the Zika virus (ZIKV). Emetine and it's analog Cephaeline were identified in a high-throughput assay aimed at identifying anti-ZIKV compounds. Both Emetine and Cephaeline are potent inhibitors of ZIKV infection in cell culture, and Emeline is...

Published: 10/28/2024 | Inventor(s): Emily Lee, Wei Zheng, Miao Xu, Ruili Huang, Shu Yang, Wenwei Huang, Khalida Shamim, Hao Li, Hengli Tang

Keywords(s): compounds, Emetine, Flavivirus, Infection, Prevention, treatment, VLXXXX, WIXXXX, WKXXXX

Category(s): Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Research Materials