Search Results - retinitis+pigmentosa

3 Results

Sort By:

Gene Therapy for Treatment of CRX-Autosomal Dominant Retinopathies

Abstract: Mutations in the cone rod homeobox (CRX) transcription factor lead to distinct retinopathy phenotypes, including early-onset vision impairment in dominant Leber congenital amaurosis (LCA). Adeno-Associated virus (AAV) vector-mediated delivery of a CRX cDNA under the control of a CRX promoter region partially restored photoreceptor phenotype...

Published: 4/8/2024 | Inventor(s): Anand Swaroop, Kamil Kruczek, Suja Hiriyanna, Zhijian Wu

Keywords(s): AAV, Adeno-associated Virus, Cone-rod Dystrophy, CRD, GENE THERAPY, LCA, Leber Congenital Amaurosis, Lentivirus, NEI, rare disease, Retinitis Pigmentosa, Retinopathies, RP, Swaroop

Category(s): TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration

Metformin for the Treatment of Age-related Retinal Degeneration

Abstract: Retinal Degenerations (RD) are the leading cause of blindness in the United States. The degeneration of the Retinal Pigment Epithelium (RPE) is associated with various types of RD such as Stargardt’s disease, retinitis pigmentosa, choroideremia, Late-Onset Retinal Degeneration (L-ORD), and Age-related Macular Degeneration (AMD). The RPE as...

Published: 4/8/2024 | Inventor(s): Kapil Bharti, Kiyoharu Miyagishima, Fnu Ruchi, Justin Chang, Balendu Jha, Karla Barbosa-Sabenero, Katharina Clore-Gronenborn

Keywords(s): Age-related Macular Degeneration, AMD, Bharti, choroideremia, iPS cells, Late-Onset Retinal Degeneration, L-ORD, Metformin, RD, Retinal degeneration, Retinal Pigment Epithelium, Retinitis Pigmentosa, RPE, Stargardt’s disease

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat

Selective estrogen-receptor modulators (SERMs) confer protection against photoreceptor degeneration

Abstract: Retinal degeneration is a deteriorative condition of the human retina caused by the progressive and eventual death of photoreceptor cells. To date, no effective treatment for genetically inherited or age-associated retinal degeneration, which includes a large patient population worldwide, is available. Researchers at the National Eye Institute...

Published: 4/8/2024 | Inventor(s): Wai Wong, Lian Zhao, Xu Wang, Wenxin Ma

Keywords(s): Age-Related Degeneration, AMD, Estrogen-receptor, Microglial Inhibition, National Eye Institute, NEI, Photoreceptor, Retinal degeneration, Retinitis Pigmentosa, RP

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, Collaboration Sought > Collaboration