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Development of High-Throughput ELISA Based Binding Assays to Detect p53/p63/p73 Family Protein-DNA Interaction in the 96-well Microplate Format for Drug Screening and Other Clinical and Diagnostic Uses

This technology includes ELISA based binding assays of p53, p63 or p73 provide possibilities to validate genome sequencing results, and allow the performance of more in-depth investigation to address scientific mechanisms, as well as to develop applications for high-throughput clinical and diagnosis usages. While quantitative p53 binding assays have...

Published: 8/12/2024 | Inventor(s): Zhong Chen, Minyoung Jang

Keywords(s):

Category(s): Application > Diagnostics, Application > Research Materials, ResearchProducts > Research Equipment, TherapeuticArea > Oncology

Functions and Targets of Therapeutic MicroRNAs to Treat and Diagnose Cancer

This technology includes a method to identify potentially therapeutic microRNAs in cancer, particularly squamous cell carcinoma of the head and neck (HNSCC). This approach first utilizes a large and publicly available expression dataset, which is then validated by a smaller independent dataset to determine deregulated microRNAs expression. These results...

Published: 8/12/2024 | Inventor(s): Carter Van Waes, Anthony Saleh, Hui Cheng, Zhong Chen

Keywords(s):

Category(s): Application > Research Materials, Application > Therapeutics, TherapeuticArea > Oncology

Murine Cell Models for Metastatic Squamous Cell Carcinoma

Two cell lines isolated from Pam 212 cells (SCC): Pam LY (lymph node metastasis) and Pam LU (lung metastasis) from metastated in vivo growth in mouse. These stably established cell lines exhibited higher potential to metastasize to lymph nodes and lungs, respectively, in mouse models than their parental Pam 212 cells.

Published: 7/25/2024 | Inventor(s): Carter Van Waes, Zhong Chen

Keywords(s): AMD, BUT, CCXXXX, Establish, Including, Limit, Lines, LU, LU1, LY, LY-1, LY-2, LY-8, Pam, VCXXXX, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology