Search Results - hepatitis+e

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Neutralization of Hepatitis C Virus (HCV)

Available for licensing and commercial development are compositions and methods for preventing and/or treating infection caused by hepatitis C virus (HCV). The invention is based on mapping studies conducted by the inventors of two epitopes within HCV E2: epitope I and epitope II. It has been discovered that epitope I is involved in virus neutralization...

Published: 7/25/2024 | Inventor(s): Pei Zhang

Keywords(s): antibodies, ANTIBODY, BINDING, C, Chromosome 7, monosomy, CONTROL, DB4BXX, DB4XXX, DBXXXX, DC1XXX, DC5BXX, DC5XXX, DCXXXX, Deletion 7, DXXXXX, E2, HCV, HCV Vaccine, Hepatitis A, Hepatitis D, Hepatitis E, Hepititis, Heptitis, Infection, Interference-mediated, INTERFERING, Methods, Modulate, Neutralization, Patent Category - Chemistry, Protein, SITE, virus

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines, Application > Therapeutics

Nitrite and Nitrite-Methemoglobin Therapy to Detoxify Stroma-Free Hemoglobin Based Blood Substitutes

Cell-free hemoglobin based oxygen carriers (HBOCs) are blood substitutes and resuscitative agents that can be used to replace whole blood donations, alleviate blood shortages and reduce the risks of infections such as HIV and hepatitis. Stroma-free HBOCs offer the advantages of increased stability, consistency of supply, and reduced immunogenicity...

Published: 7/25/2024 | Inventor(s): Mark Gladwin

Keywords(s): Based, Blood, Detoxify, hemoglobin, Hepatitis A, Hepatitis D, Hepatitis E, ICXXXX, IXXXXX, Nitrite, Nitrite-methemoglobin, Stroma-free, Substitutes, THERAPY

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Diagnostics, Application > Research Materials

Hepatitis C Virus Cell Culture System

Hepatitis C virus (HCV) infection causes chronic liver disease and is a major global health problem with an estimated 170 million people affected worldwide and 3-4 million new cases every year. Therapeutic advances will be greatly aided by the ability of researchers to successfully replicate and characterize the virus in vitro. The study of HCV replication...

Published: 7/25/2024 | Inventor(s): Rodney Russell, Robert Purcell, Suzanne Emerson

Keywords(s): Cells, CULTURE, DDXXXX, DXXXXX, Hepatitis A, HEPATITIS C, Hepatitis D, Hepatitis E, Hepatocellular carcinoma, adult, HEPATOMA, Huh-7, Huh-7.5, Subclone

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Research Materials

Development of Dengue Virus Type 3 Vaccine Candidates

The disease burden associated with dengue virus infection has increased over the past several decades in the tropical and semi-tropical regions of the world, where over 2 billion people live at risk of dengue infection. Annually, there are an estimated fifty (50) to one hundred (100) million cases of dengue fever, making development of an effective...

Published: 7/25/2024 | Inventor(s): Joseph Blaney, Brian Murphy, Stephen Whitehead

Keywords(s): 1, 2, 3, 30, 3'-UTR, CANDIDATES, CONSISTING, Containing, Contiguous, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, Deletion, DELETIONS, Delta30, DEN4, DENGUE, Dengue (Flaviviridae), DENGUE FEVER, Dervived, Development, DXXXXX, Either, Genome, Hepatitis A, Hepatitis D, Hepatitis E, Iin, MULTIPLE, Nucleotdies, Nucleotide, ONE, Q fever, Regions, THAN, TYPE, UAXXXX, UBXXXX, Vaccine, virus

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease

Swine Hepatitis E Virus Available For Use in Diagnosis, Prevention and Treatment of Hepatitis E

Hepatitis E virus (HEV) is the cause of Hepatitis E, a liver disease that occurs primarily in developing countries due to fecal contaminated drinking water. Outbreaks of HEV infection have caused epidemics in Africa, Central and Southeast Asia and Mexico and cases of the disease have also been reported sporadically in more developed countries. Hepatitis...

Published: 7/25/2024 | Inventor(s): Suzanne Emerson, Robert Purcell, Xiang-jin Meng

Keywords(s): DC5BXX, DC5XXX, DCXXXX, Duke DNA Project, DXXXXX, e, Hepatitis, Hepatitis A, Hepatitis D, Hepatitis E, HEV, PCT/US98/14665, Swine, THEREOF, UAXXXX, USES, virus

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Infectious Disease, Application > Vaccines

Monoclonal Antibodies That Bind or Neutralize Hepatitis B Virus

Hepatitis B virus (HBV) chronically infects over 300 million people worldwide. Many of them will die of chronic hepatitis or hepatocellular carcinoma. The present technology relates to the isolation and characterization of a novel neutralizing chimpanzee monoclonal antibody to HBV. The antibody was identified through a combinatorial antibody library...

Published: 7/25/2024 | Inventor(s): Robert Purcell, Suzanne Emerson

Keywords(s): ANTIBODY, B, Chimpanzee, DB4BXX, DB4XXX, DBXXXX, DDXXXX, DXXXXX, Hepatitis, Hepatitis A, Hepatitis D, Hepatitis E, monoclonal, Neutralizes, That, virus

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Therapeutics

Accelerated Vaccination Strategies to Provide Protection Against Viral Infections

The technology described in this patent application relates to recombinant viruses for use as vaccines. These viruses contain a single or plurality of sequences encoding antigens from pathogenic viruses heterologous to the recombinant virus. The antigenic sequences from pathogens such as influenza, RSV, measles, HPV, Epstein-Barr, Lassa, Polio, West...

Published: 7/25/2024 | Inventor(s): Gary Nabel

Keywords(s): DC5BXX, DCXXXX, Dengue (Flaviviridae), DXXXXX, Hepatitis A, Hepatitis D, Hepatitis E, HTLV-1, HTLV-2, HTLV-3, Human T Cell Leukemia Virus 1, Human T-cell leukemia viruses type 2, Human T-lymphotropic virus type 3, MEASLES

Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Infectious Disease

Four Chimpanzee Monoclonal Antibodies that Neutralize Hepatitis A Virus

This invention claims antibodies and/or fragments thereof specific for hepatitis A virus (HAV) and the use of the antibodies in the diagnosis, prevention, and treatment of hepatitis A. Hepatitis A is the most common type of hepatitis reported in the United States, which reports an estimated 134,000 cases annually, and infects at least 1.4 million people...

Published: 7/25/2024 | Inventor(s): Darren Schofield, Suzanne Emerson, Robert Purcell

Keywords(s): DB4BXX, DBXXXX, DCXXXX, DXXXXX, Hepatitis A, Hepatitis D, Hepatitis E

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines

Major Neutralization Site of Hepatitis E Virus and Use of this Neutralization Site in Methods of Vaccination

Hepatitis E is endemic in many countries throughout the developing world, in particular on the continents of Africa and Asia. The disease generally affects young adults and has a very high mortality rate, up to 20%, in pregnant women. This invention relates to the identification of a neutralization site of hepatitis E virus (HEV) and neutralizing...

Published: 7/25/2024 | Inventor(s): Suzanne Emerson, Robert Purcell

Keywords(s): DC5BXX, DCXXXX, DXXXXX, Hepatitis A, Hepatitis D, Hepatitis E

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines

Recombinant Proteins of the Swine Hepatitis E Virus and Their Uses as a Vaccine and Diagnostic Reagents for Medical and Veterinary Applications

This invention is based on the discovery of the swine hepatitis E virus (swine HEV), the first animal strain of HEV identified and characterized, and its ability to infect across species. The inventors have found that the swine HEV is widespread in the general pig population in the United States and other countries and that swine HEV can infect non-human...

Published: 7/25/2024 | Inventor(s): Xiang-jin Meng, Robert Purcell, Suzanne Emerson

Keywords(s): DA4BXX, DAXXXX, DC5BXX, DCXXXX, DXXXXX, Hepatitis A, Hepatitis D, Hepatitis E

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease

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