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Novel NMDA ligands that are specific and selective to the NR2B subunits based on the derivatives of 7-methoxy-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ol

This invention includes the design and synthesis of ligands that bind selectively and specifically to the NR2B subunit of the NMDA receptor. The NMDA receptor is thought to play a role in the pathophysiology of psychiatric disorders, including depression, stroke, drug addiction, and neuropathic pain. Existing ligands to the NMDA receptor are widely...

Published: 7/25/2024 | Inventor(s): Victor Pike, Lisheng Cai

Keywords(s): 3, 4, 5-tetrahydro-1H-benzo[d]azepin-1-ol, 7-methoxy-3-4-phenylbutyl-2, Based, Derivatives, LIGANDS, NR2B, VNXXXX, WIXXXX

Category(s): Application > Research Materials, TherapeuticArea > Psychiatry/Mental Health

DNA Methylation Based Non-invasive Blood Diagnostic Assay for Precision Cancer Detection and Classification

This technology includes a panel of 46 genomic loci of DNA methylation (represented by CpG dinucleotides on different chromosomes) with application in blood-based cancer screening. The markers robustly distinguish tumor from normal samples using 8 loci and classify 13 different tumor types. Using 39 loci, inventors were able to discriminate between...

Published: 7/25/2024 | Inventor(s): Gennady Margolin, Laura Elnitski

Keywords(s): assay, Based, Blood, CANCER, CLASSIFICATION, Detection, diagnostic, DNA, Humans, Methylation, NON-INVASIVE, PRECISION, VCXXXX, WBXXXX, WIXXXX, XEXXXX

Category(s): Application > Research Materials, Application > Diagnostics, TherapeuticArea > Oncology, Application > Therapeutics

Simple, Field-Usable Fluorescence-Based Isothermal LAMP Assay for the On-Site Diagnosis of Malaria

CDC researchers have developed improved Loop-Mediated Isothermal Amplification (LAMP) assays for the nucleic acid-based diagnosis of malaria in field settings. The approach employs Plasmodium genus-specific LAMP primers and a portable tube scanner to run the LAMP reaction and measure fluorescence signal (e.g., SYBR green) as a measure of DNA amplification...

Published: 7/25/2024 | Inventor(s): Allison Demas, Naomi Lucchi, Venkatachalam Udhayakumar

Keywords(s): assay, Based, CDC Docket Import, CDC Docket Import CDC Prosecuting, CDCRM, DA2XXX, DAXXXX, DDXXXX, DEVELOPING, Development, Diagnosis, diagnostic, DXXXXX, Field-usable, Fluorescence, Isothermal, ivd, LAMP, LIMITED-RESOURCE, LOW INPUT, Malaria, Mosquito, Mosquitoes, nucleic acid, NUCLEIC ACID DETECTION, PCR ALTERNATIVE, real time, REAL-TIME, SIMPLE, travel, traveler, travelers, VBXXXX, Vector-borne, Vector-borne diseases, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WAXXXX, WBXXXX, WDXXXX, WFXXXX, WIXXXX, WMXXXX, YBXXXX, Zoonotic

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Occupational Safety and Health, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Consumer Products

A Novel Scaffold for Multivalent Display of Ligands

Multivalent interactions are important in cell attachment, wound healing and immune responses. Such interactions are associated with cancer metastasis, blood clotting and the generation of antibodies from a vaccination. Mimicking multivalent interactions on a synthetic scaffold is challenging especially when large numbers of ligands (such as 5 or more)...

Published: 7/25/2024 | Inventor(s): Daniel Appella

Keywords(s): AAXXXX, AXXXXX, Based, Chain-Modified, DISPLAY, LIGANDS, MULTIVALENT, Nanostructures, PNA, PNAfor, PROGRAMMABLE, Self-assembled, SIDE, Sidechain-Modified, YXXXXX

Category(s): Collaboration Sought > Collaboration

Nitrite and Nitrite-Methemoglobin Therapy to Detoxify Stroma-Free Hemoglobin Based Blood Substitutes

Cell-free hemoglobin based oxygen carriers (HBOCs) are blood substitutes and resuscitative agents that can be used to replace whole blood donations, alleviate blood shortages and reduce the risks of infections such as HIV and hepatitis. Stroma-free HBOCs offer the advantages of increased stability, consistency of supply, and reduced immunogenicity...

Published: 7/25/2024 | Inventor(s): Mark Gladwin

Keywords(s): Based, Blood, Detoxify, hemoglobin, Hepatitis A, Hepatitis D, Hepatitis E, ICXXXX, IXXXXX, Nitrite, Nitrite-methemoglobin, Stroma-free, Substitutes, THERAPY

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Diagnostics, Application > Research Materials

A Fold-Back Diabody Format for Diphtheria Toxin-Based Immunotoxins That Can Increase Binding and Potency

NIH inventors, in collaboration with Scott and White Memorial Hospital inventors, have developed new immunotoxins comprising a mutant diphtheria toxin linked to an anti-prostate specific membrane antigen (PSMA) fold-back diabody. The fold-back diabody construct has a shortened linker region between the heavy and light chains of the antibody variable...

Published: 7/25/2024 | Inventor(s): David Neville

Keywords(s): A-dmDT390scfbDb591, Anti-prostratic, APPLICATION, Based, BINDING, CANCER, CB1AXX, CB1BXX, CB1CXX, CB1XXX, CBXXXX, CXXXXX, Diabody, DIPHTHERIA, Diptheria, Fold-back, FORMAT, Immunotoxin, IMMUNOTOXINS, INCREASE, particular, Potentcy, That, toxin

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Immunology, Application > Therapeutics

Cell-Nanofiber Composite and Cell-Nanofiber Composite Amalgam Based Engineered Intervertebral Disc

Diseased or damaged musculoskeletal tissues are often replaced by an artificial material, cadaver tissue or donated, allogenic tissue. Tissue engineering offers an attractive alternative whereby a live, natural tissue is generated from a construct made up of a patient’s own cells or an acceptable/compatible cell source in combination with a biodegradable...

Published: 8/12/2024 | Inventor(s): Rocky Tuan, Leon Nesti, Wan-Ju Li

Keywords(s): AB1XXX, AB3AXX, AB3CXX, AB3GXX, AB3XXX, ABXXXX, Amalgam, AXXXXX, Based, Cell-nanofiber, Composite, DISC, ENGINEERED, Intervertebra

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available

Retrovirus Packaging Cell Lines Based on Gibbon Ape Leukemia Virus

Gene therapy and gene transfer have recently been recognized as effective therapeutic tools to combat diseases. Accordingly, market demands for vectors and carriers to facilitate such interventions have surged in recent years. Retroviral vectors provide an efficient and safe means of gene transfer to eukaryotic cells. The present invention relates to...

Published: 7/25/2024 | Inventor(s): Maribeth Eiden

Keywords(s): APE, Based, Cell, Duke DNA Project, GCXXXX, GIBBON, GXXXXX, IDXXXX, IXXXXX, Leukemia, Lines, LT CASE, Packaging, Retrovirus, virus, WIXXXX

Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Therapeutics