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A Fold-Back Diabody Format for Diphtheria Toxin-Based Immunotoxins That Can Increase Binding and Potency
Case ID:
TAB-1711
Web Published:
12/6/2022
Description:
NIH inventors, in collaboration with Scott and White Memorial Hospital inventors, have developed new immunotoxins comprising a mutant diphtheria toxin linked to an anti-prostate specific membrane antigen (PSMA) fold-back diabody. The fold-back diabody construct has a shortened linker region between the heavy and light chains of the antibody variable domain. This construct allows interactions between the longer-linked variable domains while preventing interactions between the shorter-linked variable domains. This results in increased efficiency of epitope recognition and delivery to the appropriate target cells. These immunotoxins can be used for the treatment of cancers that overexpress PMSA, with specific application against prostate cancer.
Patent Information:
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App Type
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Serial No.
Patent No.
File Date
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Patent Status
Direct Link:
https://nih.technologypublisher.com/tech/A_Fold-Back_Diabody_Format_for_Dipht heria_Toxin-Based_Immunotoxins_That_Can_Increase_Binding_and_Potency
Category(s):
Collaboration
Oncology
Immunology
Therapeutics
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For Information, Contact:
Jennifer Wong
Technology Development Coordinator
NIH Technology Transfer
301-828-3707
jennifer.wong2@nih.gov
Inventors:
David Neville
Keywords:
A-dmDT390scfbDb591
Anti-prostratic
APPLICATION
Based
BINDING
CANCER
CB1AXX
CB1BXX
CB1CXX
CB1XXX
CBXXXX
CXXXXX
Diabody
DIPHTHERIA
Diptheria
Fold-back
FORMAT
Immunotoxin
IMMUNOTOXINS
INCREASE
particular
Potentcy
That
toxin
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