Search Results - cb1cxx

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A Fold-Back Diabody Format for Diphtheria Toxin-Based Immunotoxins That Can Increase Binding and Potency

NIH inventors, in collaboration with Scott and White Memorial Hospital inventors, have developed new immunotoxins comprising a mutant diphtheria toxin linked to an anti-prostate specific membrane antigen (PSMA) fold-back diabody. The fold-back diabody construct has a shortened linker region between the heavy and light chains of the antibody variable...

Published: 7/25/2024 | Inventor(s): David Neville

Keywords(s): A-dmDT390scfbDb591, Anti-prostratic, APPLICATION, Based, BINDING, CANCER, CB1AXX, CB1BXX, CB1CXX, CB1XXX, CBXXXX, CXXXXX, Diabody, DIPHTHERIA, Diptheria, Fold-back, FORMAT, Immunotoxin, IMMUNOTOXINS, INCREASE, particular, Potentcy, That, toxin

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Immunology, Application > Therapeutics

Long Acting Therapeutic Conjugates with Evans Blue

This invention is a platform technology that pertains to the advantages of conjugating therapeutics to Evans Blue thus providing long lasting pharmacokinetic profiles by complexing with albumin. Notably, albumin bound therapeutic- or prodrug-Evans Blue conjugates provide a complex with a total molecular size above 60 kDa thus eliminating the risk for...

Published: 7/25/2024 | Inventor(s): Gang NIU, Lixin Lang, Xiaoyuan (Shawn) Chen

Keywords(s): Albumin, blood brain barrier, CB1CXX, Central Nervous System, CONJUGATED, Conjugation, DIABETES, Evans Blue, IB6XXX, PXXXXX, RENAL CLEARANCE, therapeutics, VCXXXX, VDXXXX, VEXXXX, VFXXXX, VPXXXX, WJXXXX, WKXXXX, YCXXXX

Category(s): Collaboration Sought > Licensing, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Infectious Disease, TherapeuticArea > Neurology, TherapeuticArea > Cardiology, TherapeuticArea > Reproductive Health, TherapeuticArea > Endocrinology, Application > Consumer Products, TherapeuticArea > Dental, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology, TherapeuticArea > Immunology, Application > Research Materials, Application > Diagnostics