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Simple, Field-Usable Fluorescence-Based Isothermal LAMP Assay for the On-Site Diagnosis of Malaria

CDC researchers have developed improved Loop-Mediated Isothermal Amplification (LAMP) assays for the nucleic acid-based diagnosis of malaria in field settings. The approach employs Plasmodium genus-specific LAMP primers and a portable tube scanner to run the LAMP reaction and measure fluorescence signal (e.g., SYBR green) as a measure of DNA amplification...

Published: 7/25/2024 | Inventor(s): Allison Demas, Naomi Lucchi, Venkatachalam Udhayakumar

Keywords(s): assay, Based, CDC Docket Import, CDC Docket Import CDC Prosecuting, CDCRM, DA2XXX, DAXXXX, DDXXXX, DEVELOPING, Development, Diagnosis, diagnostic, DXXXXX, Field-usable, Fluorescence, Isothermal, ivd, LAMP, LIMITED-RESOURCE, LOW INPUT, Malaria, Mosquito, Mosquitoes, nucleic acid, NUCLEIC ACID DETECTION, PCR ALTERNATIVE, real time, REAL-TIME, SIMPLE, travel, traveler, travelers, VBXXXX, Vector-borne, Vector-borne diseases, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WAXXXX, WBXXXX, WDXXXX, WFXXXX, WIXXXX, WMXXXX, YBXXXX, Zoonotic

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Occupational Safety and Health, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Consumer Products

Simple and Rapid Assay to Detect Acute Subtype B and Group M HIV-1 Infections

Within recent years, point-of-care (POC) testing has allowed for many individuals to be screened for and provided with HIV test results. It is critical to be able to accurately detect acute HIV infections as this is a stage where the risk of transmission is great. Additionally, early HIV detection could lead to less high-risk behavior, thereby reducing...

Published: 7/25/2024 | Inventor(s): Sherry Owen, Donna Rudolph, Kelly Curtis, Philip Niedzwiedz

Keywords(s): AA2XXX, AA5XXX, AAXXXX, AC1XXX, AC3XXX, AC4XXX, ACXXXX, AIDS, amplification, AXXXXX, B, CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DA4AXX, DA4XXX, DAXXXX, Detection, diagnostic, DXXXXX, Field, Field-diagnostic, Field-usable, GROUP, HIV, HIV-1, HIV-2, IN-SITU, Isothermal, LAMP, LIMITED-RESOURCE, Listed LPM Houze as of 4/15/2015, Loop-Mediated, LOW INPUT, M, Methods, NCHHSTP, OID-NCHHSTP-DHPSE, On-demand, PCR, PCR ALTERNATIVE, Portable, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RAPID, Reverse-Transcription, RT-LAMP, Subtype, viral, VIRAL DIAGNOSTIC, virus, VLXXXX, WBXXXX, WIXXXX, XCXXXX, XEXXXX, XHXXXX, YAXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment