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Neutralizing Antibodies to Influenza HA and Their Use and Identification

The effectiveness of current influenza vaccines varies by strain and season, in part because influenza viruses continuously evolve to evade human immune responses. While the majority of seasonal influenza infections cause relatively mild symptoms, each year influenza virus infections result in over 500,000 hospitalizations in the United States and Europe....

Published: 7/25/2024 | Inventor(s): Robert Bailer, Michael Joyce, John Mascola, Peter Kwong, Sarah Andrews, Paul Thomas, Gwo-Yu Chuang, Adam Wheatley, Yi Zhang, James Whittle, Adrian McDermott

Keywords(s): 1, 2, antibodies, DB4XXX, DBXXXX, DC5XXX, DCXXXX, DXXXXX, GROUP, INFLUENZA, Neutralize, That, Their, Viruses, VLXXXX, WJXXXX, WNXXXX, XAXXXX, XKXXXX, YCXXXX

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, ResearchProducts > Antibodies, TherapeuticArea > Immunology

Multivalent, Multiple-Antigenic-Peptides for Serological Detection of HIV-1 Groups -M, -N, -O, and HIV-2

This CDC-developed invention pertains to multivalent antigenic peptides (MAPs) that can be used in a variety of HIV/AIDS diagnostics. There are two types of HIV: HIV-1 and HIV-2. HIV-1 is subdivided into groups M, N, and O, while HIV-2 is subdivided into subtypes A and B. Within HIV -1 group M, several different subtypes and numerous forms of recombinant...

Published: 7/25/2024 | Inventor(s): Chou-Pong Pau

Keywords(s): 0, AAXXXX, AIDS, antibodies, ANTIGEN, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4AXX, DA4XXX, DAXXXX, Detection, DEVELOPING, DXXXXX, GROUP, HIV-1, HIV-2., LATERAL, M, MAPS, Multiple-antigenic-peptides, MULTIVALENT, N, RESEARCH MATERIAL, virus, VLXXXX, WBXXXX, WFXXXX, WIXXXX, XAXXXX, XCXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, ResearchProducts > Antibodies, TherapeuticArea > Immunology, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Infectious Disease, Application > Occupational Safety and Health, Application > Therapeutics, Application > Consumer Products

Controlled Expression and Assembly of Human Group-C Rotavirus-like Particles for Creation of Rotavirus Diagnostic Assays and Improved Vaccine Formulations

CDC researchers have developed methods of producing unlimited quantities of Group-C (GpC) rotavirus antigens. GpC rotaviruses are a major, worldwide cause of acute gastroenteritis in children and adults that is distinct from Group-A rotavirus. However, GpC rotaviruses cannot be grown in culture, resulting in a lack of tools for detection and treatment...

Published: 7/25/2024 | Inventor(s): Baoming Jiang

Keywords(s): C, CDC Docket Import, CDC Docket Import CDC Prosecuting, CHILDHOOD, Children, DA4BXX, DA4XXX, DAXXXX, DB4BXX, DB4XXX, DBXXXX, DC1XXX, DC5BXX, DC5XXX, DCXXXX, DXXXXX, GROUP, Human, NEONATAL, Neonates, OID-NCIRD-DVD, PARTICLES, rotavirus, Their, THEREOF, viral, Viral-Like, virus, VLXXXX, VOXXXX, VPXXXX, WBXXXX, WFXXXX, WIXXXX, WMXXXX, XAXXXX, XCXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, ResearchProducts > Antibodies, TherapeuticArea > Cardiology, Application > Research Materials, Application > Occupational Safety and Health, Application > Vaccines, TherapeuticArea > Endocrinology, Application > Diagnostics, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology, Application > Consumer Products, TherapeuticArea > Dental

Peptide Vaccines Against Group A Streptococci

This invention relates to synthetic immunoreactive peptides, which are portions of the M proteins of the most prevalent Group A Streptococcus (GAS) serotypes in the United States. These peptides may be useful in development of a flexible, multivalent GAS vaccine. They can be recognized by M type-specific antibodies and are capable of eliciting functional...

Published: 7/25/2024 | Inventor(s): George Carlone, Jacquelyn Sampson, Edwin Ades, Bernard Beall

Keywords(s): Against, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DAXXXX, DB3XXX, DBXXXX, DC4XXX, DCXXXX, GROUP, OID-NCIRD-DBD, Peptide, Streptococci, vaccines

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease

Simple and Rapid Assay to Detect Acute Subtype B and Group M HIV-1 Infections

Within recent years, point-of-care (POC) testing has allowed for many individuals to be screened for and provided with HIV test results. It is critical to be able to accurately detect acute HIV infections as this is a stage where the risk of transmission is great. Additionally, early HIV detection could lead to less high-risk behavior, thereby reducing...

Published: 7/25/2024 | Inventor(s): Sherry Owen, Donna Rudolph, Kelly Curtis, Philip Niedzwiedz

Keywords(s): AA2XXX, AA5XXX, AAXXXX, AC1XXX, AC3XXX, AC4XXX, ACXXXX, AIDS, amplification, AXXXXX, B, CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DA4AXX, DA4XXX, DAXXXX, Detection, diagnostic, DXXXXX, Field, Field-diagnostic, Field-usable, GROUP, HIV, HIV-1, HIV-2, IN-SITU, Isothermal, LAMP, LIMITED-RESOURCE, Listed LPM Houze as of 4/15/2015, Loop-Mediated, LOW INPUT, M, Methods, NCHHSTP, OID-NCHHSTP-DHPSE, On-demand, PCR, PCR ALTERNATIVE, Portable, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RAPID, Reverse-Transcription, RT-LAMP, Subtype, viral, VIRAL DIAGNOSTIC, virus, VLXXXX, WBXXXX, WIXXXX, XCXXXX, XEXXXX, XHXXXX, YAXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment