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p300 KO HEK293T Cell Line for Multiple Research Applications

This technology includes p300 KO HEK293T cells using crispr/cas9 mediated gene editing technology to be used for various research applications. We showed that p300 deficient cells have impaired glycolysis and are hypersensitive to glucose depletion-induced cell death. p300 is one of major transcriptional co-activators that regulates gene transcription...

Published: 8/12/2024 | Inventor(s): Ming Ji, Xiaoling Li

Keywords(s):

Category(s): Application > Research Materials, ResearchProducts > Human Cell Lines, TherapeuticArea > Neurology

Novel Human Rotavirus Vaccine CDC-6 Strain for Impacted Subgroup, the Lewis Negative Population

Rotaviral infection is the most common gastrointestinal illness of children in the world, affecting both developed and developing economies. There is no specific drug treatment for rotavirus infection. Vaccination and good hygiene are key to prevention. Approximately 5-10% of the world's population are Lewis histoblood group antigen negative, that percentage...

Published: 7/25/2024 | Inventor(s): Yuhuan Wang, Baoming Jiang

Keywords(s): Candidate, CHARACTERIZATION, G9P[6], Human, Isolation, NCIRD, NCIRD-DVD, rotavirus, Strain, Vaccine, VLXXXX, WBXXXX, WFXXXX, WGXXXX, WHXXXX, WIXXXX, WNXXXX, XKXXXX, YAXXXX, YBXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines, Application > Consumer Products, Application > Diagnostics, Application > Research Materials, Application > Occupational Safety and Health

A Novel Thermal Method to Inactivate Rotavirus for Use in Vaccines

Rotavirus is a highly contagious, diarrhea-inducing pathogen that annually causes approximately 250,000 deaths worldwide and millions of hospitalizations, especially afflicting infants and young children. One strategy to combat this virus is through vaccination. Continuing safety and efficacy concerns with the currently existing live, oral vaccines...

Published: 7/25/2024 | Inventor(s): Roger Glass, Jean-Francois Saluzzo, Baoming Jiang

Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, DB4BXX, DB4XXX, DBXXXX, DC1XXX, DC5BXX, DC5XXX, DCXXXX, DXXXXX, Inactivation, Listed LPM Surabian as of 4/15/2015, NCIRD, OID-NCIRD-DVD, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, rotavirus, thermal

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Therapeutics

Controlled Expression and Assembly of Human Group-C Rotavirus-like Particles for Creation of Rotavirus Diagnostic Assays and Improved Vaccine Formulations

CDC researchers have developed methods of producing unlimited quantities of Group-C (GpC) rotavirus antigens. GpC rotaviruses are a major, worldwide cause of acute gastroenteritis in children and adults that is distinct from Group-A rotavirus. However, GpC rotaviruses cannot be grown in culture, resulting in a lack of tools for detection and treatment...

Published: 7/25/2024 | Inventor(s): Baoming Jiang

Keywords(s): C, CDC Docket Import, CDC Docket Import CDC Prosecuting, CHILDHOOD, Children, DA4BXX, DA4XXX, DAXXXX, DB4BXX, DB4XXX, DBXXXX, DC1XXX, DC5BXX, DC5XXX, DCXXXX, DXXXXX, GROUP, Human, NEONATAL, Neonates, OID-NCIRD-DVD, PARTICLES, rotavirus, Their, THEREOF, viral, Viral-Like, virus, VLXXXX, VOXXXX, VPXXXX, WBXXXX, WFXXXX, WIXXXX, WMXXXX, XAXXXX, XCXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, ResearchProducts > Antibodies, TherapeuticArea > Cardiology, Application > Research Materials, Application > Occupational Safety and Health, Application > Vaccines, TherapeuticArea > Endocrinology, Application > Diagnostics, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology, Application > Consumer Products, TherapeuticArea > Dental

Human Rotavirus Strains and Vaccines for Neonatal Childhood Protection

This invention relates to rotavirus vaccine compositions and methods of vaccination. Rotaviral infection is the most commonly occurring gastrointestinal illness of children world, affecting both developed and developing economies. Additionally, rotavirus infections can affect livestock (especially calves and piglets), and resulting mortality/morbidity...

Published: 7/25/2024 | Inventor(s): Roger Glass, Yuhuan Wang, Jon Gentsch, Baoming Jiang

Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, CHILDHOOD, Children, DB4BXX, DB4XXX, DBXXXX, DC5BXX, DC5XXX, DCXXXX, DEVELOPED, DEVELOPING, DIARRHEA, DXXXXX, Dysentery, GASTRIC, gastrointestinal, Human, Livestock, NEONATAL, Neonates, OID-NCIRD-DVD, rotavirus, Strain, STRAINS, Vaccine, VETERINARY, VETERINARY vaccine, viral, virus, VLXXXX, VOXXXX, WIXXXX, WJXXXX, WMXXXX, XEXXXX, XHXXXX, YBXXXX, YCXXXX, Zoo, Zoonotic

Category(s): Collaboration Sought > Licensing, Application > Research Materials, ResearchProducts > Research Equipment, Application > Vaccines, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Infectious Disease