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p300 KO HEK293T Cell Line for Multiple Research Applications

This technology includes p300 KO HEK293T cells using crispr/cas9 mediated gene editing technology to be used for various research applications. We showed that p300 deficient cells have impaired glycolysis and are hypersensitive to glucose depletion-induced cell death. p300 is one of major transcriptional co-activators that regulates gene transcription...

Published: 8/12/2024 | Inventor(s): Ming Ji, Xiaoling Li

Keywords(s):

Category(s): Application > Research Materials, ResearchProducts > Human Cell Lines, TherapeuticArea > Neurology

SIRT1 KO Human Cell Lines Generated by CRISPR/Cas9-mediated DNA Editing

SIRT1, a NAD+-dependent protein deacetylase, is the most conserved member of the sirtuins family. Through deacetylation of a number of protein substrates that are important transcription factors or co-factors, SIRT1 regulates many vital biological processes such as metabolism, cellular stress response, stem cell pluripotency, and development. The present...

Published: 10/28/2024 | Inventor(s): Yi Fang, Xiaoling Li

Keywords(s): Cell, CRISPER/Cas9-mediated, DNA, Editing, GENERATED, Human, KO, Lines, SIRT1, VCXXXX, VFXXXX, VPXXXX, WIXXXX, XEXXXX, YAXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Application > Research Materials