Search Results - sirt1

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Sirt1 LoxP (Sirt1tm1Cxd) Mouse Model for Metabolism and Hepatology Studies

Generation of floxed Sirtuin 1 Exon5-Exon6 for the construction of conditional knockout mice. Sirtuin 1 (Sirt1), a homolog of yeast Sir 2, is an NAD-dependent histone and protein deacetylase. It has a wide range of biological functions, ranging from DNA damage repair to effects on glucose metabolism. Sirt1 null mice die before birth due to chromosomal...

Published: 7/25/2024 | Inventor(s): Chuxia Deng

Keywords(s): 1, IDXXXX, IXXXXX, LOXP, Mouse, Sirt, SIRT1, Tm1Cxd

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics

Sirt1 Knockout (Sirt1tm1.1Cxd) Mouse Model for Oncology and Metabolism Studies

Sirt1 knockout: Sirt1, a protein deacetylase, is a tumor suppressor that promotes genome stability and regulates proteins involved in energy metabolism. Yeast Sir2, a nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylase, has been implicated in chromatin silencing, longevity and genome stability. Mammals contain a family of related...

Published: 7/25/2024 | Inventor(s): Chuxia Deng

Keywords(s): CCXXXX, cre-lox, Cre-loxP, CXXXXX, GCXXXX, GXXXXX, IDXXXX, IXXXXX, knockout mice, Mouse, Mouse animal model, SIRT1, Tm1.1Cxd

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology, Application > Diagnostics, Application > Research Materials

SIRT1 KO Human Cell Lines Generated by CRISPR/Cas9-mediated DNA Editing

SIRT1, a NAD+-dependent protein deacetylase, is the most conserved member of the sirtuins family. Through deacetylation of a number of protein substrates that are important transcription factors or co-factors, SIRT1 regulates many vital biological processes such as metabolism, cellular stress response, stem cell pluripotency, and development. The present...

Published: 7/25/2024 | Inventor(s): Yi Fang, Xiaoling Li

Keywords(s): Cell, CRISPER/Cas9-mediated, DNA, Editing, GENERATED, Human, KO, Lines, SIRT1, VCXXXX, VFXXXX, VPXXXX, WIXXXX, XEXXXX, YAXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Application > Research Materials