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Fgfr2 Knockout (Fgfr2tm1Cxd) Mouse Model for Developmental Biology Studies

FGFR2 knockout is an embryonic lethal mutation and blocks limb bud initiation. Fibroblast Growth Factor Receptor 2 (FGFR2) is a high affinity receptor for several members of the FGF family. The FGFR2 gene was inactivated by deleting the entire immunoglobulin-like domain of the receptor which is critical for FGF binding and FGFR2 activity. Embryos...

Published: 7/25/2024 | Inventor(s): Chuxia Deng

Keywords(s): FGFR2, IDXXXX, IXXXXX, Knock, Mouse, Tm1Cxd

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics

Fgfr3 Knockout Mouse Model for Developmental Biology Studies

FGFR3 knockout. Complete knockout of the FGFR3 gene, the gene in which missense mutants cause short statue achondroplasia, fails to restrain cartilage growth at the bone growth plate, allowing bones to elongate excessively but fail to ossify. Endochondral ossification is a major mode of bone formation. Cartilage proliferates, undergoes hypertrophy,...

Published: 7/25/2024 | Inventor(s): Chuxia Deng

Keywords(s): FGFR3, IDXXXX, IXXXXX, Knock, Mouse

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Diagnostics, Application > Research Materials

Sirt1 LoxP (Sirt1tm1Cxd) Mouse Model for Metabolism and Hepatology Studies

Generation of floxed Sirtuin 1 Exon5-Exon6 for the construction of conditional knockout mice. Sirtuin 1 (Sirt1), a homolog of yeast Sir 2, is an NAD-dependent histone and protein deacetylase. It has a wide range of biological functions, ranging from DNA damage repair to effects on glucose metabolism. Sirt1 null mice die before birth due to chromosomal...

Published: 7/25/2024 | Inventor(s): Chuxia Deng

Keywords(s): 1, IDXXXX, IXXXXX, LOXP, Mouse, Sirt, SIRT1, Tm1Cxd

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics

Sirt6 LoxP (Sirt6tm1.1Cxd) Mouse Model for Liver Studies

Generation of floxed Sirtuin 6 for the construction of conditional knockout mice. The Sirtuins (Sirt1-7), a family of seven proteins related to yeast Sir2, are histone deacetylases that regulate many critical biological processes including genomic stability, adaptation to calorie restriction and aging. Mice with a targeted disruption of Sirt6 had very...

Published: 7/25/2024 | Inventor(s): Chuxia Deng

Keywords(s): IDXXXX, IXXXXX, LOXP, Mouse, Sirt6, Sirt6tm1.1Cxd, Tm1.1Cxd

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics

Sirt1 Knockout (Sirt1tm1.1Cxd) Mouse Model for Oncology and Metabolism Studies

Sirt1 knockout: Sirt1, a protein deacetylase, is a tumor suppressor that promotes genome stability and regulates proteins involved in energy metabolism. Yeast Sir2, a nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylase, has been implicated in chromatin silencing, longevity and genome stability. Mammals contain a family of related...

Published: 7/25/2024 | Inventor(s): Chuxia Deng

Keywords(s): CCXXXX, cre-lox, Cre-loxP, CXXXXX, GCXXXX, GXXXXX, IDXXXX, IXXXXX, knockout mice, Mouse, Mouse animal model, SIRT1, Tm1.1Cxd

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology, Application > Diagnostics, Application > Research Materials

Sirt3 Knockout (Sirt3tm1.1Cxd) Mouse Model for Cardiology and Metabolism Studies

Sirt3 knockout: Sirt3 is a mitochondrial-localized tumor suppressor that maintains mitochondrial integrity and metabolism during stress. Sirt3 is a mitochondrial protein that is a member of the Sirtuin family of NAD-dependent protein deacetylases. Sirt3(-/-) mice are phenotypically normal, but exhibit many proteins whose acetylation is increased....

Published: 7/25/2024 | Inventor(s): Chuxia Deng

Keywords(s): cre-lox, Cre-loxP, IDXXXX, IXXXXX, Knock, Mouse, Sirt3, Tm1.1Cxd, Tm1Cxd

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics

Fgfr4 Knockout Mouse Model for Respiratory System Studies

FGFR4 knockout: Lung alveoli fail to develop normally in double mutant with FGFR4 and FGFR3 knockouts. The fibroblast growth factor receptor 4 (fgfr-4) gene was inactivated by targeted disruption and homozygous recombination to study its possible role in lung development. FGFR-4 is expressed in postnatal lung, and FGFR-4 null mice have no obvious abnormalities....

Published: 4/8/2024 | Inventor(s): Chuxia Deng

Keywords(s): 4, factor, FGFR4, Fibroblast, Generation, Growth, IDXXXX, IXXXXX, Knockout, Mice, RECEPTOR

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics

Smad4 Knockout (Smad4tm1Cxd) Mouse Model for Developmental Biology Studies

Smad4 knockout: Smad4 is essential for epiblast proliferation, egg cylinder formation and mesoderm induction in early embryogenesis. The TGF-beta-related superfamily plays an important role in multiple biological systems including embryogenesis. TGF-beta ligands activate specific receptors, which interact with specific Smad proteins, which in turn...

Published: 4/8/2024 | Inventor(s): Chuxia Deng

Keywords(s): DPC4-Null, Generation, IDXXXX, IXXXXX, Mice, SUPPRESSOR, tumor

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Research Materials, Application > Diagnostics

Fibroblast Growth Factor Receptor 1 (Fgfr1) Conditional Knock Out Mouse

Scientists at NIDDK have developed a fibroblast growth factor receptor 1 (Fgfr1) conditional knock out mouse. Fgfr1 is a member of the Fgfr family of transmembrane protein receptors with intrinsic tyrosine kinase activity. Fgfr1 is important in multiple biological processes, including mesoderm induction and patterning, cell growth and migration, organ...

Published: 7/25/2024 | Inventor(s): Chuxia Deng

Keywords(s): 1, AC5XXX, ACXXXX, AXXXXX, Conditional, factor, FGFR1, Fibroblast, Growth, Knockout, Mice, RECEPTOR

Category(s): Collaboration Sought > Licensing

Generation of Smad3-null Mice and Smad4-conditional Mice

SMADs are a novel set of mammalian proteins that act downstream of TGF-beta family ligands. These proteins can be categorized into three distinct functional sets, receptor-activated SMADs (SMADs 1,2,3,5, and 8), the common mediator SMAD (SMAD 4), and inhibitory SMADs (SMADs 6 and 7). SMAD proteins are thought to play a role in vertebrate development...

Published: 4/8/2024 | Inventor(s): Chuxia Deng

Keywords(s): 3-@hydroxyacyl-coa dehydrogenase deficiency, BAXXXX, HAD deficiency, HIS deficiency, Histidinemia, IDXXXX, IXXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, ResearchProducts > Animal Models, Application > Research Materials, Application > Diagnostics

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