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Fgfr3 Knockout Mouse Model for Developmental Biology Studies

FGFR3 knockout. Complete knockout of the FGFR3 gene, the gene in which missense mutants cause short statue achondroplasia, fails to restrain cartilage growth at the bone growth plate, allowing bones to elongate excessively but fail to ossify. Endochondral ossification is a major mode of bone formation. Cartilage proliferates, undergoes hypertrophy,...

Published: 7/25/2024 | Inventor(s): Chuxia Deng

Keywords(s): FGFR3, IDXXXX, IXXXXX, Knock, Mouse

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Diagnostics, Application > Research Materials