Search Results - tm1cxd

3 Results

Sort By:

Fgfr2 Knockout (Fgfr2tm1Cxd) Mouse Model for Developmental Biology Studies

FGFR2 knockout is an embryonic lethal mutation and blocks limb bud initiation. Fibroblast Growth Factor Receptor 2 (FGFR2) is a high affinity receptor for several members of the FGF family. The FGFR2 gene was inactivated by deleting the entire immunoglobulin-like domain of the receptor which is critical for FGF binding and FGFR2 activity. Embryos...

Published: 7/25/2024 | Inventor(s): Chuxia Deng

Keywords(s): FGFR2, IDXXXX, IXXXXX, Knock, Mouse, Tm1Cxd

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics

Sirt1 LoxP (Sirt1tm1Cxd) Mouse Model for Metabolism and Hepatology Studies

Generation of floxed Sirtuin 1 Exon5-Exon6 for the construction of conditional knockout mice. Sirtuin 1 (Sirt1), a homolog of yeast Sir 2, is an NAD-dependent histone and protein deacetylase. It has a wide range of biological functions, ranging from DNA damage repair to effects on glucose metabolism. Sirt1 null mice die before birth due to chromosomal...

Published: 7/25/2024 | Inventor(s): Chuxia Deng

Keywords(s): 1, IDXXXX, IXXXXX, LOXP, Mouse, Sirt, SIRT1, Tm1Cxd

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics

Sirt3 Knockout (Sirt3tm1.1Cxd) Mouse Model for Cardiology and Metabolism Studies

Sirt3 knockout: Sirt3 is a mitochondrial-localized tumor suppressor that maintains mitochondrial integrity and metabolism during stress. Sirt3 is a mitochondrial protein that is a member of the Sirtuin family of NAD-dependent protein deacetylases. Sirt3(-/-) mice are phenotypically normal, but exhibit many proteins whose acetylation is increased....

Published: 7/25/2024 | Inventor(s): Chuxia Deng

Keywords(s): cre-lox, Cre-loxP, IDXXXX, IXXXXX, Knock, Mouse, Sirt3, Tm1.1Cxd, Tm1Cxd

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics