Search Results - suzanne+emerson

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Hepatitis C virus (HCV) infection causes chronic liver disease and is a major global health problem with an estimated 170 million people affected worldwide and 3-4 million new cases every year. Therapeutic advances will be greatly aided by the ability of researchers to successfully replicate and characterize the virus in vitro. The study of HCV replication...

Published: 7/25/2024 | Inventor(s): Rodney Russell, Robert Purcell, Suzanne Emerson

Keywords(s): Cells, CULTURE, DDXXXX, DXXXXX, Hepatitis A, HEPATITIS C, Hepatitis D, Hepatitis E, Hepatocellular carcinoma, adult, HEPATOMA, Huh-7, Huh-7.5, Subclone

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Research Materials

Monoclonal Antibodies Against Orthopoxviruses

Concerns that variola (smallpox) virus might be used as a biological weapon have led to the recommendation of widespread vaccination with vaccinia virus. While vaccination is generally safe and effective for prevention of smallpox, it is well documented that various adverse reactions in individuals have been caused by vaccination with existing licensed...

Published: 7/25/2024 | Inventor(s): Bernard Moss, Suzanne Emerson, Robert Purcell, Patricia Earl, Zhaochun Chen

Keywords(s): Against, antibodies, DAXXXX, DB4BXX, DB4XXX, DBXXXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, DXXXXX, monoclonal, ORTHOPOXVIRUSES

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease

Monoclonal Antibodies that Neutralize B. anthracis Protective Antigen (PA), Lethal Factor (LF) and Edema Factor (EF)

Anthrax, whether resulting from natural or bioterrorist-associated exposure, is a constant threat to human health. The lethality of anthrax is primarily the result of the effects of anthrax toxin, which has 3 components: a receptor-binding protein known as "protective antigen" (PA) and 2 catalytic proteins known as "lethal factor" (LF) and "edema factor"...

Published: 7/25/2024 | Inventor(s): Stephen Leppla, Suzanne Emerson, Robert Purcell, Mahtab Moayeri, Zhaochun Chen

Keywords(s): Anthrax, antibodies, ANTIBODY, ANTIGEN, Chimpaneze, DA3XXX, DAXXXX, DB3XXX, DBXXXX, DC4XXX, DCXXXX, DDXXXX, DXXXXX, Edema, FACTORS, Lethal, monoclonal, Neutralize, Neutralizes, PA, Protective, That, toxin, UAXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Rare / Neglected Diseases, Application > Therapeutics, TherapeuticArea > Infectious Disease

Swine Hepatitis E Virus Available For Use in Diagnosis, Prevention and Treatment of Hepatitis E

Hepatitis E virus (HEV) is the cause of Hepatitis E, a liver disease that occurs primarily in developing countries due to fecal contaminated drinking water. Outbreaks of HEV infection have caused epidemics in Africa, Central and Southeast Asia and Mexico and cases of the disease have also been reported sporadically in more developed countries. Hepatitis...

Published: 7/25/2024 | Inventor(s): Suzanne Emerson, Robert Purcell, Xiang-jin Meng

Keywords(s): DC5BXX, DC5XXX, DCXXXX, Duke DNA Project, DXXXXX, e, Hepatitis, Hepatitis A, Hepatitis D, Hepatitis E, HEV, PCT/US98/14665, Swine, THEREOF, UAXXXX, USES, virus

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Infectious Disease, Application > Vaccines

Neutralizing Monoclonal Antibodies to Botulinum Neurotoxin Type A

Two chimpanzee mAbs specifically reacted with light chain of the botulinum neurotoxin A and neutralize the toxin in the mouse model. They can be used for emergency prophylaxis and treatment of either naturally acquired or terrorist associated botulism. Since the sequence of chimpanzee immune globulin is virtually identical to that of humans, the MAbs...

Published: 7/25/2024 | Inventor(s): Robert Purcell, Suzanne Emerson, Zhaochun Chen

Keywords(s): Botulinum, DB3XXX, DBXXXX, DXXXXX, Hybridoma, Listed LPM Chang as of 4/15/2015, mabs, Neurotoxin, Neutralizing, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RM, UA1XXX, VJXXXX, WAXXXX, WIXXXX, XAXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Rare / Neglected Diseases, Application > Diagnostics, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease, ResearchProducts > Antibodies

Monoclonal Antibodies That Bind or Neutralize Hepatitis B Virus

Hepatitis B virus (HBV) chronically infects over 300 million people worldwide. Many of them will die of chronic hepatitis or hepatocellular carcinoma. The present technology relates to the isolation and characterization of a novel neutralizing chimpanzee monoclonal antibody to HBV. The antibody was identified through a combinatorial antibody library...

Published: 7/25/2024 | Inventor(s): Robert Purcell, Suzanne Emerson

Keywords(s): ANTIBODY, B, Chimpanzee, DB4BXX, DB4XXX, DBXXXX, DDXXXX, DXXXXX, Hepatitis, Hepatitis A, Hepatitis D, Hepatitis E, monoclonal, Neutralizes, That, virus

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Therapeutics

Four Chimpanzee Monoclonal Antibodies that Neutralize Hepatitis A Virus

This invention claims antibodies and/or fragments thereof specific for hepatitis A virus (HAV) and the use of the antibodies in the diagnosis, prevention, and treatment of hepatitis A. Hepatitis A is the most common type of hepatitis reported in the United States, which reports an estimated 134,000 cases annually, and infects at least 1.4 million people...

Published: 7/25/2024 | Inventor(s): Darren Schofield, Suzanne Emerson, Robert Purcell

Keywords(s): DB4BXX, DBXXXX, DCXXXX, DXXXXX, Hepatitis A, Hepatitis D, Hepatitis E

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines

Major Neutralization Site of Hepatitis E Virus and Use of this Neutralization Site in Methods of Vaccination

Hepatitis E is endemic in many countries throughout the developing world, in particular on the continents of Africa and Asia. The disease generally affects young adults and has a very high mortality rate, up to 20%, in pregnant women. This invention relates to the identification of a neutralization site of hepatitis E virus (HEV) and neutralizing...

Published: 7/25/2024 | Inventor(s): Suzanne Emerson, Robert Purcell

Keywords(s): DC5BXX, DCXXXX, DXXXXX, Hepatitis A, Hepatitis D, Hepatitis E

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines

Recombinant Proteins of the Swine Hepatitis E Virus and Their Uses as a Vaccine and Diagnostic Reagents for Medical and Veterinary Applications

This invention is based on the discovery of the swine hepatitis E virus (swine HEV), the first animal strain of HEV identified and characterized, and its ability to infect across species. The inventors have found that the swine HEV is widespread in the general pig population in the United States and other countries and that swine HEV can infect non-human...

Published: 7/25/2024 | Inventor(s): Xiang-jin Meng, Robert Purcell, Suzanne Emerson

Keywords(s): DA4BXX, DAXXXX, DC5BXX, DCXXXX, DXXXXX, Hepatitis A, Hepatitis D, Hepatitis E

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease

Infectious cDNA Clone of GB Virus B and Uses Thereof

The current invention provides nucleic acid sequences comprising the genomes of infectious GB virus B, the most closely related member of the Flaviviridae to hepatitis C virus (HCV). It also covers chimeric GBVB-HCV sequences and polypeptides for use in the development of vaccines and diagnostic assays for HCV and the development of screening assays...

Published: 7/25/2024 | Inventor(s): Jens Bukh, Masayuki Yanagi, Robert Purcell, Suzanne Emerson

Keywords(s): DC5XXX, DCXXXX, DDXXXX, DXXXXX, Hepatitis A, Hepatitis D, Hepatitis E

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Vaccines

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