Search Results - mahtab+moayeri

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Plasmids Encoding and Producing Anthrax Toxin Proteins

Plasmid pSJ136-EF-A — A plasmid encoding mutant anthrax toxin proteins such as lethal factor (LF) or edema factor (EF). Anthrax toxin and anthrax toxin fusion proteins may be used as therapeutic agents for cancer. Plasmid PSJ115-LFOS — A plasmid expressing anthrax toxin proteins such as lethal factor (LF) or edema factor (EF) which has the original...

Published: 7/25/2024 | Inventor(s): Pradeep Gupta, Yiu Cheung, Haijing Hu, Mahtab Moayeri, Stephen Leppla

Keywords(s): Anthrax, Improved, Listed LPM Soukas as of 4/15/2015, Methods, PLASMID, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, production, proteins, RM, TOXINS, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials

Monoclonal Antibodies that Neutralize B. anthracis Protective Antigen (PA), Lethal Factor (LF) and Edema Factor (EF)

Anthrax, whether resulting from natural or bioterrorist-associated exposure, is a constant threat to human health. The lethality of anthrax is primarily the result of the effects of anthrax toxin, which has 3 components: a receptor-binding protein known as "protective antigen" (PA) and 2 catalytic proteins known as "lethal factor" (LF) and "edema factor"...

Published: 7/25/2024 | Inventor(s): Stephen Leppla, Suzanne Emerson, Robert Purcell, Mahtab Moayeri, Zhaochun Chen

Keywords(s): Anthrax, antibodies, ANTIBODY, ANTIGEN, Chimpaneze, DA3XXX, DAXXXX, DB3XXX, DBXXXX, DC4XXX, DCXXXX, DDXXXX, DXXXXX, Edema, FACTORS, Lethal, monoclonal, Neutralize, Neutralizes, PA, Protective, That, toxin, UAXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Rare / Neglected Diseases, Application > Therapeutics, TherapeuticArea > Infectious Disease

Modulators of Nuclear Hormone Receptor Activity: Novel Compounds, Diverse Applications for Infectious Diseases, Including Anthrax B. anthracis

Nuclear hormones such as glucocorticoids dampen inflammatory responses, and thus provide protection to mammals against inflammatory disease and septic shock. The Anthrax lethal factor represses nuclear hormone receptor activity, and thus may contribute to the infectious agent causing even more damage to the host. This observation can be exploited...

Published: 8/12/2024 | Inventor(s): Esther Sternberg, Jeanette Webster, Leonardo Tonelli, Stephen Leppla, Mahtab Moayeri

Keywords(s): Anthrax, BBXXXX, DA3XXX, DAXXXX, DB3XXX, DBXXXX, DDXXXX, DXXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Infectious Disease, Application > Therapeutics