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Modulators of Nuclear Hormone Receptor Activity: Novel Compounds, Diverse Applications for Infectious Diseases, Including Anthrax B. anthracis

Nuclear hormones such as glucocorticoids dampen inflammatory responses, and thus provide protection to mammals against inflammatory disease and septic shock. The Anthrax lethal factor represses nuclear hormone receptor activity, and thus may contribute to the infectious agent causing even more damage to the host. This observation can be exploited...

Published: 8/12/2024 | Inventor(s): Esther Sternberg, Jeanette Webster, Leonardo Tonelli, Stephen Leppla, Mahtab Moayeri

Keywords(s): Anthrax, BBXXXX, DA3XXX, DAXXXX, DB3XXX, DBXXXX, DDXXXX, DXXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Infectious Disease, Application > Therapeutics