HOME
SEARCH
RSS FEED
SUBSCRIBE
Recombinant Proteins of the Swine Hepatitis E Virus and Their Uses as a Vaccine and Diagnostic Reagents for Medical and Veterinary Applications
Case ID:
TAB-519
Web Published:
12/6/2022
Description:
This invention is based on the discovery of the swine hepatitis E virus (swine HEV), the first animal strain of HEV identified and characterized, and its ability to infect across species. The inventors have found that the swine HEV is widespread in the general pig population in the United States and other countries and that swine HEV can infect non-human primates. The inventors have amplified and sequenced the complete genome of swine HEV. The capsid gene (ORF2) of swine HEV has been cloned and expressed in a baculovirus expression system.
The possibility that swine HEV may infect humans raises a potential public health concern for zoonosis or xenozoonosis in the United States and perhaps other countries. Therefore, it is likely that a vaccine based on the recombinant capsid protein of swine HEV will protect humans against zoonotic, as well as other, HEV infections and pigs against infection with the swine HEV. Also, diagnostic reagents based on these recombinant proteins of swine HEV will be very useful in screening donor pigs used in xenotransplantation and in detecting swine HEV or similar virus infection in humans. The diagnostic reagents may also be useful for veterinary studies and monitoring pig herds in general.
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Patent Status
Direct Link:
https://nih.technologypublisher.com/tech/Recombinant_Proteins_of_the_Swine_He patitis_E_Virus_and_Their_Uses_as_a_Vaccine_and_Diagnostic_Reagents_for_Medi cal_and_Veterinary_Applications
Category(s):
Licensing
Diagnostics
Vaccines
Infectious Disease
Bookmark this page
Download as PDF
For Information, Contact:
Peter Soukas
Technology Licensing Specialist/TTPS
NIH Technology Transfer
301-496-2644
peter.soukas@nih.gov
Inventors:
Xiang-jin Meng
Robert Purcell
Suzanne Emerson
Keywords:
DA4BXX
DAXXXX
DC5BXX
DCXXXX
DXXXXX
Hepatitis A
Hepatitis D
Hepatitis E
Home
|
Search
|
RSS
|
Subscribe
© 2024. All Rights Reserved. Powered by
Inteum