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Antigenic Chimeric Tick-Borne Encephalitis Virus/Dengue Virus Type 4 Recombinant Viruses

The tick-borne encephalitis virus (TBEV) complex is a group of viruses that can cause severe neutrotropic disease and up to thirty percent (30%) mortality. While these viruses can be found in many parts of the world, the largest impact of the disease occurs in Europe and Russia, where approximately fourteen thousand (14,000) hospitalized TBEV cases...

Published: 7/25/2024 | Inventor(s): Brian Murphy, Amber Engel, Alexander Pletnev

Keywords(s): 4, ANTIGENIC, CANDIDATES, CAUSED, chimeric, Chromosome 7, monosomy, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, Deletion 7, Dengue (Flaviviridae), Development, Disease, DXXXXX, ENCEPHALITIS, Patent Category - Biotechnology, Prevention, recombinant, TBEV, TBEV/DEN4, TICK-BORNE, Tick-borne encephalitis, TYPE, Vaccine, virus, Virus/dengue, Viruses

Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease

Development of Dengue Virus Type 3 Vaccine Candidates

The disease burden associated with dengue virus infection has increased over the past several decades in the tropical and semi-tropical regions of the world, where over 2 billion people live at risk of dengue infection. Annually, there are an estimated fifty (50) to one hundred (100) million cases of dengue fever, making development of an effective...

Published: 7/25/2024 | Inventor(s): Joseph Blaney, Brian Murphy, Stephen Whitehead

Keywords(s): 1, 2, 3, 30, 3'-UTR, CANDIDATES, CONSISTING, Containing, Contiguous, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, Deletion, DELETIONS, Delta30, DEN4, DENGUE, Dengue (Flaviviridae), DENGUE FEVER, Dervived, Development, DXXXXX, Either, Genome, Hepatitis A, Hepatitis D, Hepatitis E, Iin, MULTIPLE, Nucleotdies, Nucleotide, ONE, Q fever, Regions, THAN, TYPE, UAXXXX, UBXXXX, Vaccine, virus

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease

Peptide Mimotope Candidates for Otitis Media Vaccine

This technology describes peptide mimotopes of lipooligosaccharides (LOS) from nontypeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis that are suitable for developing novel vaccines against the respective pathogens, for which there are currently no licensed vaccines. The mimotopes not only immunologically mimic LOSs from NTHi and M. catarrhalis...

Published: 7/25/2024 | Inventor(s): Xin-xing Gu

Keywords(s): BCXXXX, CANDIDATES, DC5BXX, DC5XXX, DCXXXX, Development, DXXXXX, H. Influenzae, HAEMOPHILUS, HAEMOPHILUS INFLUENZ, Haemophilus influenzae, INFLUENZA, Lipoligosaccharide, MIMICING AGENT, Minotopes, NONTYPEABLE, OTITIS MEDIA, Peptide, Peptides, UAXXXX, Vaccine

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Infectious Disease

Live Attenuated Zika Virus Vaccine

This application claims live attenuated Zika viruses and vaccines, attenuated chimeric Zika viruses and vaccines, and multivalent immunogenic compositions comprising Zika vaccines and vaccines for other flaviviruses. The chimeric Zika viruses claimed include a first nucleotide sequence encoding at least one structural protein from a Zika virus (ZIKV),...

Published: 7/25/2024 | Inventor(s): Sara Woodson, Anna Durbin, Alexander Pletnev, Konstantin Tsetsarkin, Stephen Whitehead

Keywords(s): Attenuated, CANDIDATES, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, DXXXXX, Live, Vaccine, virus, Zika

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Vaccines, Application > Research Materials, TherapeuticArea > Infectious Disease