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Moraxella Catarrhalis Lipooligosaccharide Based Conjugate Vaccines for the Prevention of Otitis Media and Respiratory Infections

Moraxella catarrhalis is one of the three leading causative agents of otitis media in children. This is due in part to the current immunizations of children with Streptococcus pneumoniae polysaccharide and conjugate vaccines to prevent otitis media. The proportion of otitis media caused by pneumococcal strains covered by the vaccines have decreased...

Published: 7/25/2024 | Inventor(s): John Robbins, Xin-xing Gu

Keywords(s): BBXXXX, BCXXXX, BRANHAMELLA, CATARHALIS, Catarrhalis, DC4XXX, DCXXXX, DETOXIFIED, DXXXXX, HAEMOPHILUS, Haemophilus influenzae, Humans, Immunization, INFECTIONS, INFLUENZAE, Intranasal, Lipooligosaccharide, LIPOOLIGOSACCHARIDE-BASED, MORAXELLA, NONTYPEABLE, OTITIS MEDIA, Patent Category - Biotechnology, Prevention, Tetanus, UAXXXX, Vaccine, With...

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Vaccines, TherapeuticArea > Rare / Neglected Diseases

Conjugate Vaccine for Neisseria Meningitidis

The invention discloses a vaccine which comprises lipooligosaccharide (LOS) isolated from N. meningitidis and conjugated to a carrier protein. The invention also discloses a method of making the acellular vaccine. The method consists of two main steps. In the first step the lipooligosaccharide (LOS), chosen so it does not contain the lacto-N-neotetraose...

Published: 7/25/2024 | Inventor(s): Xin-xing Gu, Chao-ming Tsai

Keywords(s): DC4XXX, DCXXXX, DXXXXX, Neisseria meningitidis, Tetanus

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines

Modified Bacterial Strain for Otitis Media Vaccine

This invention relates to a strain of Moraxella catarrhalis containing a gene mutation that prevents endotoxic lipooligosaccharide (LOS) synthesis and potential use of the mutant for developing novel vaccines against the pathogen, for which there is currently no licensed vaccine. M. catarrhalis is one of the causative agents of otitis media (middle...

Published: 7/25/2024 | Inventor(s): Xin-xing Gu, Daxin Peng

Keywords(s): DC4XXX, DCXXXX, DXXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, TherapeuticArea > Infectious Disease, Application > Vaccines

Peptide Mimotope Candidates for Otitis Media Vaccine

This technology describes peptide mimotopes of lipooligosaccharides (LOS) from nontypeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis that are suitable for developing novel vaccines against the respective pathogens, for which there are currently no licensed vaccines. The mimotopes not only immunologically mimic LOSs from NTHi and M. catarrhalis...

Published: 7/25/2024 | Inventor(s): Xin-xing Gu

Keywords(s): BCXXXX, CANDIDATES, DC5BXX, DC5XXX, DCXXXX, Development, DXXXXX, H. Influenzae, HAEMOPHILUS, HAEMOPHILUS INFLUENZ, Haemophilus influenzae, INFLUENZA, Lipoligosaccharide, MIMICING AGENT, Minotopes, NONTYPEABLE, OTITIS MEDIA, Peptide, Peptides, UAXXXX, Vaccine

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Infectious Disease