Search Results - infections

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Salen-Manganese Compounds for Therapy of Viral Infections

Salen-manganese compounds are synthetic, stable, low toxicity, low cost agents that may provide protection from immune reaction-related oxidative cell damage associated with many illnesses. In particular, oxidative cell damage has been associated with many viral infections including influenza. This invention demonstrates that treating mice with salen-manganese...

Published: 7/25/2024 | Inventor(s): Jeffery Taubenberger, Rodney Levine, Susan Doctrow, John Kash

Keywords(s): Catalase/Superoxide, DB4BXX, DB4XXX, DBXXXX, DISMUTASE, DXXXXX, INFECTIONS, MIMETICS, Synthetic, viral

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Infectious Disease

Prevention and Treatment of Herpes Virus Infection by Inhibition of the JMJD2 Family of Histone Demethylases

Investigators at the NIH have discovered a potential means for preventing or treating a herpes virus infection by inhibiting the activity of the host cell’s histone demethylases. When herpesviruses enter a cell, they are inactivated by cellular defense mechanisms that wrap the viral genome in repressive chromatin structures. In order for viral replication...

Published: 7/25/2024 | Inventor(s): Yu Liang, Jodi Vogel, Jesse Arbuckle, Thomas Kristie

Keywords(s): Analogs, Chicken pox, CYTOMEGALOVIRUS, DB4XXX, DBXXXX, DEPLETION, Dimethyloxalylglycine, DMOG, DXXXXX, ENZYMES, Ester, FAMILY, HERPES, INFECTIONS, Inhibitors, JMJD, Kaposi Sarcoma, Kaposi's sarcoma; Kaposi sarcoma, Latency, Methyl, N-methoxyoxoacetyl-glycine, Patent Category - Chemistry, Prevent, Reactivation, simplex, Varicella Zoster, virus

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease

Moraxella Catarrhalis Lipooligosaccharide Based Conjugate Vaccines for the Prevention of Otitis Media and Respiratory Infections

Moraxella catarrhalis is one of the three leading causative agents of otitis media in children. This is due in part to the current immunizations of children with Streptococcus pneumoniae polysaccharide and conjugate vaccines to prevent otitis media. The proportion of otitis media caused by pneumococcal strains covered by the vaccines have decreased...

Published: 7/25/2024 | Inventor(s): John Robbins, Xin-xing Gu

Keywords(s): BBXXXX, BCXXXX, BRANHAMELLA, CATARHALIS, Catarrhalis, DC4XXX, DCXXXX, DETOXIFIED, DXXXXX, HAEMOPHILUS, Haemophilus influenzae, Humans, Immunization, INFECTIONS, INFLUENZAE, Intranasal, Lipooligosaccharide, LIPOOLIGOSACCHARIDE-BASED, MORAXELLA, NONTYPEABLE, OTITIS MEDIA, Patent Category - Biotechnology, Prevention, Tetanus, UAXXXX, Vaccine, With...

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Vaccines, TherapeuticArea > Rare / Neglected Diseases

Use of Mono-Amine Oxidase Inhibitors to Prevent Herpes Virus Infections and Reactivation from Latency

Available for licensing are methods of using Monoamine Oxidase Inhibitors (MAOIs) to prevent alpha-herpesvirus lytic infections, such as those caused by Herpes simplex virus (HSV-1 or HSV-2) and Varicella zoster virus (VZV), and to possibly prevent the periodic reactivation of these viruses from latency. MAOIs have been historically used to treat depression,...

Published: 7/25/2024 | Inventor(s): Yu Liang, Thomas Kristie

Keywords(s): BBXXXX, CHEMISTRY, DB4BXX, DB4XXX, DBXXXX, DXXXXX, HERPES, HSV, HSV-1, hsv-2, Infection, INFECTIONS, Inhibitors, Latency, Mono-Amine, Mono-Anine, OXIDASE, Prevent, Reactivation, Reactiviation, Simpex, simplex, Variacella-zoster, Varicella Zoster, virus, VZV, ZOSTER

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease