Search Results - depletion

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Minibody for Conditioning prior to Hematopoietic Stem Cell and Progenitor Cell Transplantation

Patient conditioning is a critical initial step in hematopoietic stem and progenitor cell (HSPC) transplantation procedures to enable marrow engraftment of infused cells. Conditioning regimens have traditionally been achieved by delivering cytotoxic doses of chemotherapeutic agents and radiation. However, these regimens are associated with significant...

Published: 7/25/2024 | Inventor(s): Daisuke Araki, Diogo Magnani, Zhirui Wang, Andre Larochelle

Keywords(s): 1CXXXX, 2IXXXX, 2JXXXX, Anti-cMPL, Cells, DEPLETION, Divalent, DT-390-Conjugated, hematopoietic, Progenitor, ScFv, Stem, VCXXXX, VPXXXX, WJXXXX, WMXXXX, XAXXXX

Category(s): TherapeuticArea > Ophthalmology, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, Application > Consumer Products, Application > Therapeutics, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, ResearchProducts > Antibodies

Alloreactive T Cell Depletion Method For Preventing Graft-Versus-Host Disease

The invention relates to the use of adenosine to deplete alloreactive T cells from donor grafts to prevent graft-versus-host disease (GVHD). The method includes culturing donor cells that include T cells with recipient antigen presenting cells (APCs) to form a mixture of cells. The recipient’s APCs activate donor T cells. The activated T cells are...

Published: 7/25/2024 | Inventor(s): Gregory Whitehill, John Barrett, Dhanalakshmi (Donna) Chinnasamy

Keywords(s): Alloreactive, Cell, DEPLETION, Disease, DONOR, GRAFTS, GRAFT-VERSUS-HOST, GVHD, Listed LPM Maddox as of 4/15/2015, LYMPHOCYTE, lymphocytes, Method, Novel, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Prevent, SELECTIVE, Stem, T, YAXXXX

Category(s): Collaboration Sought > Licensing

Prevention and Treatment of Herpes Virus Infection by Inhibition of the JMJD2 Family of Histone Demethylases

Investigators at the NIH have discovered a potential means for preventing or treating a herpes virus infection by inhibiting the activity of the host cell’s histone demethylases. When herpesviruses enter a cell, they are inactivated by cellular defense mechanisms that wrap the viral genome in repressive chromatin structures. In order for viral replication...

Published: 7/25/2024 | Inventor(s): Yu Liang, Jodi Vogel, Jesse Arbuckle, Thomas Kristie

Keywords(s): Analogs, Chicken pox, CYTOMEGALOVIRUS, DB4XXX, DBXXXX, DEPLETION, Dimethyloxalylglycine, DMOG, DXXXXX, ENZYMES, Ester, FAMILY, HERPES, INFECTIONS, Inhibitors, JMJD, Kaposi Sarcoma, Kaposi's sarcoma; Kaposi sarcoma, Latency, Methyl, N-methoxyoxoacetyl-glycine, Patent Category - Chemistry, Prevent, Reactivation, simplex, Varicella Zoster, virus

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease