Search Results - cytomegalovirus

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Prevention and Treatment of Herpes Virus Infection by Inhibition of the JMJD2 Family of Histone Demethylases

Investigators at the NIH have discovered a potential means for preventing or treating a herpes virus infection by inhibiting the activity of the host cell’s histone demethylases. When herpesviruses enter a cell, they are inactivated by cellular defense mechanisms that wrap the viral genome in repressive chromatin structures. In order for viral replication...

Published: 7/25/2024 | Inventor(s): Yu Liang, Jodi Vogel, Jesse Arbuckle, Thomas Kristie

Keywords(s): Analogs, Chicken pox, CYTOMEGALOVIRUS, DB4XXX, DBXXXX, DEPLETION, Dimethyloxalylglycine, DMOG, DXXXXX, ENZYMES, Ester, FAMILY, HERPES, INFECTIONS, Inhibitors, JMJD, Kaposi Sarcoma, Kaposi's sarcoma; Kaposi sarcoma, Latency, Methyl, N-methoxyoxoacetyl-glycine, Patent Category - Chemistry, Prevent, Reactivation, simplex, Varicella Zoster, virus

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease

Enhanced Distribution of Therapeutic Agents After Local Delivery

Many experimental therapies will rely on the local parenchymal delivery of macromolecules or nucleic acids for their success. However, the volume of distribution of many of these potential therapeutic agents is restricted by their interactions with the extracellular matrix and cellular receptors. Heparin-sulfate proteoglycans are cell surface components...

Published: 7/25/2024 | Inventor(s): Kryzstof Bankiewicz

Keywords(s): CYTOMEGALOVIRUS, GBXXXX, GXXXXX, NBXXXX, NXXXXX

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Neurology