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Minibody for Conditioning prior to Hematopoietic Stem Cell and Progenitor Cell Transplantation

Patient conditioning is a critical initial step in hematopoietic stem and progenitor cell (HSPC) transplantation procedures to enable marrow engraftment of infused cells. Conditioning regimens have traditionally been achieved by delivering cytotoxic doses of chemotherapeutic agents and radiation. However, these regimens are associated with significant...

Published: 7/25/2024 | Inventor(s): Daisuke Araki, Diogo Magnani, Zhirui Wang, Andre Larochelle

Keywords(s): 1CXXXX, 2IXXXX, 2JXXXX, Anti-cMPL, Cells, DEPLETION, Divalent, DT-390-Conjugated, hematopoietic, Progenitor, ScFv, Stem, VCXXXX, VPXXXX, WJXXXX, WMXXXX, XAXXXX

Category(s): TherapeuticArea > Ophthalmology, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, Application > Consumer Products, Application > Therapeutics, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, ResearchProducts > Antibodies

Human iPSC-Derived Mesodermal Precursor Cells and Differentiated Cells

Cells, cell culture methods, and cell culture media compositions useful for producing and maintaining iPSC-derived cell lines that are of higher purity and maintain cell type integrity better than current iPSC-derived cell lines are disclosed. Human induced pluripotent stem cells (hiPSCs) can be generated by reprogramming somatic cells by the expression...

Published: 7/25/2024 | Inventor(s): Guibin Chen, Mahendra Rao, Andre Larochelle, Manfred Boehm

Keywords(s): Cells, Hematopoetic, Human, IB6XXX, IDXXXX, IPSC-derived, Screenings, THERAPIES, Toxicology/drug, Vascular-related, VAXXXX, VBXXXX, VCXXXX, VDXXXX, VEXXXX, VFXXXX, VGXXXX, VHXXXX, VIXXXX, VJXXXX, VKXXXX, VLXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WGXXXX, WHXXXX, WIXXXX, WJXXXX, WKXXXX, WMXXXX, YAXXXX, YBXXXX, YCXXXX