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Alloreactive T Cell Depletion Method For Preventing Graft-Versus-Host Disease

The invention relates to the use of adenosine to deplete alloreactive T cells from donor grafts to prevent graft-versus-host disease (GVHD). The method includes culturing donor cells that include T cells with recipient antigen presenting cells (APCs) to form a mixture of cells. The recipient’s APCs activate donor T cells. The activated T cells are...

Published: 7/25/2024 | Inventor(s): Gregory Whitehill, John Barrett, Dhanalakshmi (Donna) Chinnasamy

Keywords(s): Alloreactive, Cell, DEPLETION, Disease, DONOR, GRAFTS, GRAFT-VERSUS-HOST, GVHD, Listed LPM Maddox as of 4/15/2015, LYMPHOCYTE, lymphocytes, Method, Novel, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Prevent, SELECTIVE, Stem, T, YAXXXX

Category(s): Collaboration Sought > Licensing

Image Guided Systems and Methods for Organ Viability Assessment

The number of patients for organ transplants continues to grow, without an increase in the number of organs available for transplant. This has increased interest in transplanting organs from non-traditional sources, such as donations after cardiac death. However, there are currently no methods to objectively measure the effects of resuscitation and...

Published: 7/25/2024 | Inventor(s): Allan Kirk, Eric Elster, Frederick Gage, Alexander Gorbach

Keywords(s): AA1XXX, AA3BXX, AA3XXX, AAXXXX, ASSESSMENT, AXXXXX, DEVICE, DONOR, During, Guided, Image, Method, ORGANS, ORS to NIBIB, Resuscitation, VIABILITY

Category(s): Collaboration Sought > Licensing