Search Results - joseph+blaney

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Multivalent Vaccines for Rabies Virus and Filoviruses

No vaccine candidates against Ebola virus (EBOV) or Marburg virus (MARV) are nearing licensure and the need to develop a safe and efficacious vaccine against filoviruses continues. Whereas several preclinical vaccine candidates against EBOV or MARV exist, their further development is a major challenge based on safety concerns, pre-existing vector immunity,...

Published: 7/25/2024 | Inventor(s): Jason Paragas, Reed Johnson, Peter Jahrling, Joseph Blaney

Keywords(s): Against, Bivalent, Confer, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DC6XXX, DCXXXX, DDXXXX, Dual, DXXXXX, Ebola, Ebola virus disease, INACTIVATED, Live-Attenuated, Marburg hemorrhagic fever, Protection, rabies, That, UAXXXX, vaccines, Viruses

Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Rare / Neglected Diseases

Generation of Wild-Type Dengue Viruses for Use in Rhesus Monkey Infection Studies

Dengue virus is a positive-sense RNA virus belonging to the Flavivirus genus of the family Flaviviridae. Dengue virus is widely distributed throughout the tropical and semitropical regions of the world and is transmitted to humans by mosquito vectors. Dengue virus is a leading cause of hospitalization and death in children in at least eight tropical...

Published: 7/25/2024 | Inventor(s): Joseph Blaney, Stephen Whitehead

Keywords(s): (4)r syndrome, C syndrome, Chromosome 4 ring syndrome, Chromosome 6 ring syndrome, Chromosome 7 ring syndrome, DA4BXX, DA4XXX, DAXXXX, DB4XXX, DBXXXX, DCXXXX, DDXXXX, DENGUE, Dengue (Flaviviridae), DENGUE FEVER, DXXXXX, G syndrome, Generation, Hemorrhagic fever, Hypertelorism with esophageal abnormality and hypospadias, Infection, MONKEY, N syndrome, Q fever, R(6) syndrome, R(7) syndrome, RHESUS, STUDIES, Syndrome X, Viruses, W syndrome, W syndrome; Syndrome W, WILD-TYPE, Yellow fever

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease

Development of Dengue Virus Type 3 Vaccine Candidates

The disease burden associated with dengue virus infection has increased over the past several decades in the tropical and semi-tropical regions of the world, where over 2 billion people live at risk of dengue infection. Annually, there are an estimated fifty (50) to one hundred (100) million cases of dengue fever, making development of an effective...

Published: 7/25/2024 | Inventor(s): Joseph Blaney, Brian Murphy, Stephen Whitehead

Keywords(s): 1, 2, 3, 30, 3'-UTR, CANDIDATES, CONSISTING, Containing, Contiguous, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, Deletion, DELETIONS, Delta30, DEN4, DENGUE, Dengue (Flaviviridae), DENGUE FEVER, Dervived, Development, DXXXXX, Either, Genome, Hepatitis A, Hepatitis D, Hepatitis E, Iin, MULTIPLE, Nucleotdies, Nucleotide, ONE, Q fever, Regions, THAN, TYPE, UAXXXX, UBXXXX, Vaccine, virus

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease

Dengue Tetravalent Vaccine Containing a Common 30 Nucleotide Deletion in the 3'-UTR of Dengue Types 1, 2, 3, and 4

The invention relates to a dengue virus tetravalent vaccine containing a common 30-nucleotide deletion (delta30) in the 3'-untranslated region (UTR) of the genome of dengue virus serotypes 1, 2, 3, and 4. The previously identified delta30 attenuating mutation, created in dengue virus type 4 (DEN4) by the removal of 30 nucleotides from the 3'-UTR, is...

Published: 7/25/2024 | Inventor(s): Brian Murphy, Lewis Markoff, Barry Falgout, Kathryn Hanley, Joseph Blaney, Stephen Whitehead

Keywords(s): 3'-UTR, ANTIGENIC, chimeric, Chromosome 7, monosomy, DA4BXX, DA4XXX, DAXXXX, DB4BXX, DB4XXX, DBXXXX, DC5BXX, DC5XXX, DCXXXX, Deletion, Deletion 7, DENGUE, Dengue (Flaviviridae), DXXXXX, Nucleotide, Tetravalent, UAXXXX, UBXXXX, Vaccine, Viruses

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, Application > Diagnostics, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines

Live Attenuated Vaccine to Prevent Disease Caused by West Nile Virus

West Nile virus (WNV) has recently emerged in the U.S. and is considered a significant emerging disease that has embedded itself over a considerable region of the U.S. WNV infections have been recorded in humans as well as in different animals. From 1999-2014, WNV killed 1,765 people in the U.S. and caused severe disease in more than 41,762 others....

Published: 7/25/2024 | Inventor(s): Robert Chanock (Estate), Joseph Putnak, Brian Murphy, Joseph Blaney, Stephen Whitehead, Alexander Pletnev

Keywords(s): Chimeras, DC5BXX, DC5XXX, DCXXXX, DENGUE, Dengue (Flaviviridae), DXXXXX, Live, Nile, Vaccine, virus, VLXXXX, VOXXXX, WAXXXX, WBXXXX, West, WEST NILE VIRUS, WMXXXX, WNXXXX, XKXXXX, YCXXXX, YDXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines, Application > Consumer Products, Application > Diagnostics

Development of Mutations Useful for Attenuating Dengue Viruses and Chimeric Dengue Viruses

Although flaviviruses cause a great deal of human suffering and economic loss, there is a shortage of effective vaccines. This invention relates to dengue virus mutations that may contribute to the development of improved dengue vaccines. Site directed and random mutagenesis techniques were used to introduce mutations into the dengue virus genome...

Published: 7/25/2024 | Inventor(s): Joseph Blaney, Kathryn Hanley, Brian Murphy, Stephen Whitehead

Keywords(s): ATTENUATING, chimeric, DC5BXX, DC5XXX, DCXXXX, DENGUE, Dengue (Flaviviridae), Dengue Vaccine, Development, DXXXXX, Mutations, UAXXXX, UBXXXX, USEFUL, Viruses

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Infectious Disease