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Enterovirus Molecular Diagnostic Test Kit

CDC researchers have developed a reverse transcription/semi-nested polymerase chain reaction (RT-snPCR) assay for diagnosis of enterovirus infections within clinical specimens. Clinical laboratories currently identify enteroviruses by virus isolation and subsequent virus neutralization tests, or serological assays. In addition to being time consuming,...

Published: 7/25/2024 | Inventor(s): Mark Oberste, William Nix

Keywords(s): Acid, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4BXX, DA4XXX, DAXXXX, DETECTING, DXXXXX, Enteroviruses, Identifying, Including, Kits, MOLECULES, Nucleic, OID-NCIRD-DVD, USEFUL, VLXXXX, VOXXXX, VP1, VP3, WBXXXX, WFXXXX, WIXXXX, WMXXXX, XCXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Occupational Safety and Health, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Therapeutics

Attenuated Human Parainfluenza Virus (PIV) for Use as Live, Attenuated Vaccines and as Vector Vaccines

The identified technologies describe self-replicating infectious recombinant paramyxoviruses with one or more attenuating mutations, such as a separate variant polynucleotide encoding a P protein and a separate monocistronic polynucleotide encoding a V protein, or at least one temperature sensitive mutation and one non-temperature sensitive mutation....

Published: 7/25/2024 | Inventor(s): Peter Collins, Sheila Nolan, Mario Skiadopoulos, Brian Murphy

Keywords(s): cDNA, CIS-ACTING, Complete, DC5BXX, DC5XXX, DCXXXX, Determination, DXXXXX, FOR..., FRAMES, Gene, Generate, Generation, Genomic, HPIV2, HPIV2., HPIV2/V94, Identification, MEASLES, Mumps, MUTATION, Novel, Nucleotide, Overlapping, P/V, Parainfluenza virus type 3, Parainfluenza virus type 3; Human parainfluenza virus type 3, Reading, recombinant, rHPIV2, Separated, sequence, Strain, UA1XXX, USEFUL, V94

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, Application > Vaccines, TherapeuticArea > Infectious Disease

Development of Mutations Useful for Attenuating Dengue Viruses and Chimeric Dengue Viruses

Although flaviviruses cause a great deal of human suffering and economic loss, there is a shortage of effective vaccines. This invention relates to dengue virus mutations that may contribute to the development of improved dengue vaccines. Site directed and random mutagenesis techniques were used to introduce mutations into the dengue virus genome...

Published: 7/25/2024 | Inventor(s): Joseph Blaney, Kathryn Hanley, Brian Murphy, Stephen Whitehead

Keywords(s): ATTENUATING, chimeric, DC5BXX, DC5XXX, DCXXXX, DENGUE, Dengue (Flaviviridae), Dengue Vaccine, Development, DXXXXX, Mutations, UAXXXX, UBXXXX, USEFUL, Viruses

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Infectious Disease

A Novel Adeno-Associated Virus for Gene Therapy

Scientists at the NIH disclosed a novel adeno-associated virus (AAV) termed "44-9." AAV44-9 based vectors have high gene transfer activity in a number of cell types, including salivary gland cells, liver cells, and different types of neurons (e.g., cells of the cortex, olfactory bulb, and brain stem, and Purkinje cells of the cerebellum). These vectors...

Published: 7/25/2024 | Inventor(s): Giovanni Di Pasquale, John (Jay) Chiorini

Keywords(s): AAV, CHARACTERIZATION, Gene, Generation, Listed LPM Hu as of 4/17/2015, Novel, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, THERAPY, USEFUL, VAXXXX, VCXXXX, VEXXXX, VFXXXX, VGXXXX, WJXXXX, XEXXXX, YBXXXX, YCXXXX

Category(s): TherapeuticArea > Neurology, TherapeuticArea > Immunology, TherapeuticArea > Endocrinology, TherapeuticArea > Oncology, TherapeuticArea > Geriatrics, Application > Therapeutics