Search Results - 3%27-utr

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Development of Dengue Virus Type 3 Vaccine Candidates

The disease burden associated with dengue virus infection has increased over the past several decades in the tropical and semi-tropical regions of the world, where over 2 billion people live at risk of dengue infection. Annually, there are an estimated fifty (50) to one hundred (100) million cases of dengue fever, making development of an effective...

Published: 7/25/2024 | Inventor(s): Joseph Blaney, Brian Murphy, Stephen Whitehead

Keywords(s): 1, 2, 3, 30, 3'-UTR, CANDIDATES, CONSISTING, Containing, Contiguous, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, Deletion, DELETIONS, Delta30, DEN4, DENGUE, Dengue (Flaviviridae), DENGUE FEVER, Dervived, Development, DXXXXX, Either, Genome, Hepatitis A, Hepatitis D, Hepatitis E, Iin, MULTIPLE, Nucleotdies, Nucleotide, ONE, Q fever, Regions, THAN, TYPE, UAXXXX, UBXXXX, Vaccine, virus

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease

Dengue Tetravalent Vaccine Containing a Common 30 Nucleotide Deletion in the 3'-UTR of Dengue Types 1, 2, 3, and 4

The invention relates to a dengue virus tetravalent vaccine containing a common 30-nucleotide deletion (delta30) in the 3'-untranslated region (UTR) of the genome of dengue virus serotypes 1, 2, 3, and 4. The previously identified delta30 attenuating mutation, created in dengue virus type 4 (DEN4) by the removal of 30 nucleotides from the 3'-UTR, is...

Published: 7/25/2024 | Inventor(s): Brian Murphy, Lewis Markoff, Barry Falgout, Kathryn Hanley, Joseph Blaney, Stephen Whitehead

Keywords(s): 3'-UTR, ANTIGENIC, chimeric, Chromosome 7, monosomy, DA4BXX, DA4XXX, DAXXXX, DB4BXX, DB4XXX, DBXXXX, DC5BXX, DC5XXX, DCXXXX, Deletion, Deletion 7, DENGUE, Dengue (Flaviviridae), DXXXXX, Nucleotide, Tetravalent, UAXXXX, UBXXXX, Vaccine, Viruses

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, Application > Diagnostics, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines