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AMA1-RON2 Complex-Based Vaccine Against Malaria

This technology relates to a malaria vaccine composed of a protein complex of Apical Membrane Antigen (AMA1) and rhoptry neck protein 2 (RON2) with an adjuvant. AMA1 is a crucial component of the Plasmodium invasion machinery and is a leading candidate for antimalarial vaccine development. AMA1-based vaccines have shown ability to block red cell invasion...

Published: 7/25/2024 | Inventor(s): Louis Miller, Prakash Srinivasan

Keywords(s): Against, AMAI-RON2, CHALLENGE, COMPLEX, DC2XXX, Lethal, PLASMODIUM, Protection, PROVIDES, VACCINATION

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Vaccines

Inexpensive, Personal Dust Detector Tube/Dosimeter Operating on a Gas Detector Tube Platform

This CDC developed dust detector tube is designed to provide inexpensive, short-term, time weighted average dust exposure data feedback directly to device users. This invention operates upon a conventional gas detector tube platform and can be used with any low volume pump that can electronically measure pump back pressure. The device consists of three...

Published: 7/25/2024 | Inventor(s): Harry Dobroski, Steven Page, Jon Volkwein

Keywords(s): AE1XXX, AE2BXX, AE2XXX, AE3XXX, AEXXXX, AG3XXX, AGXXXX, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, DETECTOR, DEVICE, DUST, Enviromental, environmental health, MINING, MONITOR, NIOSH, NIOSH-PRL, Occupational health, OSHA, Protection, SAMPLER, Tube, VPXXXX, WCXXXX, WEXXXX, WFXXXX, WGXXXX, WORKER, WORKER safety, XDXXXX, XHXXXX, YEXXXX

Category(s): Collaboration Sought > Licensing, Application > Occupational Safety and Health, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology, Application > Consumer Products, TherapeuticArea > Cardiology, TherapeuticArea > Dental, TherapeuticArea > Ophthalmology, TherapeuticArea > Endocrinology, Application > Non-Medical Devices, ResearchProducts > Research Equipment, Application > Medical Devices

Ultrasonic in situ Respirator Seal-Leakage Detection with Real-time Feedback Capabilities

This CDC invention entails methods and apparatuses for in situ testing seal integrity and improved operation of respiratory masks (respirators). A variety of external factors, such as individual face shape, user environment, mask age and material used to construct the respirator, can lead to device malfunction and failure to sufficiently protect a...

Published: 7/25/2024 | Inventor(s): Jonathan Szalajda, William King

Keywords(s): AE2XXX, AE3XXX, AEROSOL, AEROSOLS, AEXXXX, AXXXXX, Biodefense, CDC Docket Import, CDC Docket Import CDC Prosecuting, DEVICE, Devices, MASK, NIOSH-NPPTL, Preventative, PROCESS, Protection, Respirator, respiratory, SAFETY, Situ, TESTING, ultrasonic, VBXXXX, VJXXXX, VKXXXX, VLXXXX, VOXXXX, VPXXXX, WAXXXX, WCXXXX, WEXXXX, WFXXXX, WGXXXX, WIXXXX, WMXXXX, XDXXXX, XIXXXX, YEXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, Application > Non-Medical Devices, Application > Medical Devices, TherapeuticArea > Oncology, Application > Consumer Products, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Occupational Safety and Health, Application > Research Materials, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, TherapeuticArea > Ophthalmology, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Cardiology

Linear Epitopes of Anthrax Toxin Protective Antigen for Development of a Peptide Vaccine

Bacillus anthracis is a gram-positive, spore-forming bacteria that causes anthrax infection in humans. CDC inventors have identified epitope sequences of B. anthracis protective antigen (PA) that may be useful for development of peptide-based anthrax vaccines. This invention also relates to methods for determining whether post-vaccination protection...

Published: 7/25/2024 | Inventor(s): Conrad Quinn, Jan Pohl, Pavel Svoboda, Shannon Dalton, Jarad Schiffer, Stephen Soroka, Vera Semenova

Keywords(s): Anthrax, ANTIGEN, Bacillus, biosecurity, Bioterrism, Bio-terrorism, Bioterrorist, BioWarfare, CDC Docket Import, CDC Docket Import CDC Prosecuting, DC1XXX, DC4XXX, DCXXXX, Development, DXXXXX, Epitopes, LINEAR, OID-NCIRD-DBD, PA, Peptide, Protection, Protective, toxin, Vaccine

Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Infectious Disease

Multivalent Vaccines for Rabies Virus and Filoviruses

No vaccine candidates against Ebola virus (EBOV) or Marburg virus (MARV) are nearing licensure and the need to develop a safe and efficacious vaccine against filoviruses continues. Whereas several preclinical vaccine candidates against EBOV or MARV exist, their further development is a major challenge based on safety concerns, pre-existing vector immunity,...

Published: 7/25/2024 | Inventor(s): Jason Paragas, Reed Johnson, Peter Jahrling, Joseph Blaney

Keywords(s): Against, Bivalent, Confer, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DC6XXX, DCXXXX, DDXXXX, Dual, DXXXXX, Ebola, Ebola virus disease, INACTIVATED, Live-Attenuated, Marburg hemorrhagic fever, Protection, rabies, That, UAXXXX, vaccines, Viruses

Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Rare / Neglected Diseases

Humanized Monoclonal Antibodies that Specifically Bind Japanese Encephalitis Virus (JEV) and Their Use

Japanese encephalitis virus (JEV) is the prototype virus of the Japanese encephalitis (JE) group belonging to the Flavivirus genus of the Flaviviridae family. Other members of the group include Kunjin virus, St. Louis encephalitis virus, and West Nile encephalitis virus (WNV). JEV is widely distributed in South Asia, Southeast Asia, and the Asian Pacific...

Published: 7/25/2024 | Inventor(s): Robert Purcell, Ching-juh Lai, Ana Goncalvez

Keywords(s): Against, antibodies, BBXXXX, Chimpanezee, DA4BXX, DA4XXX, DAXXXX, DB4XXX, DBXXXX, DC5XXX, DCXXXX, DDXXXX, DERIVED, DXXXXX, Efficient, Fabs, HUMANIZED, Infection, JAPANESE, Japanese encephalitis, JEV, Mice, monoclonal, Neutralization, Patent Category - Biotechnology, Protection, virus, Vitro

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Research Materials, Application > Diagnostics, Application > Vaccines