Search Results - conrad+quinn

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Stable, Early-stage Biomarker for Diagnosis of Bacillus anthracis Infection and Anthrax Vaccine Development

This invention comprises monoclonal antibodies, proteins, and related nucleic acid coding sequences that identify all or part of the antigenic anthrose oligosaccharide of Bacillus anthracis, the causative agent of anthrax toxicity in humans. It is imperative to identify virulent B. anthracis with speed and specificity, however there presently is substantial...

Published: 4/8/2024 | Inventor(s): Conrad Quinn, Geert-Jan Boons, Russell Carlson, Elke Saile

Keywords(s): Anthracis, ANTHROSE, antibodies, Bacillus, CDC Docket Import, CDC Docket Import NP, Cell, DA3XXX, DAXXXX, DB3XXX, DBXXXX, DEXXXX, DXXXXX, Hybridoma, Lines, monoclonal, Recognizing, SACCHARIDE, VBXXXX, VJXXXX, VOXXXX, WAXXXX, WBXXXX, WFXXXX, WIXXXX, WMXXXX, XAXXXX, XCXXXX, XEXXXX, XHXXXX, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Occupational Safety and Health, Application > Therapeutics, ResearchProducts > Antibodies, TherapeuticArea > Immunology, Application > Research Materials, Application > Diagnostics, ResearchProducts > Research Equipment

Exposure and Activity Detection Assays for Anthrax Lethal Factor and Lethal Toxin

This CDC developed invention identifies an assay for extremely fast and sensitive detection of Bacillus anthracis lethal toxin (LTx), the toxin responsible for the lethal effects of anthrax infection. This assay has already been successfully tested in animals and will allow for early detection of anthrax exposure and screening of lethal factors to...

Published: 7/25/2024 | Inventor(s): Conrad Quinn, John Barr, Anne Boyer

Keywords(s): 02706, AA5XXX, AAXXXX, Anthrax, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DA5XXX, DAXXXX, Detection, Diagnosis, diagnostic, Diagnostic assay, diagnostic in vitro, DXXXXX, FACTORS, I01306, I-013-06, I-027-06, ONDIEH-NCEH, Pathogenicity, VBXXXX, VJXXXX, VOXXXX, WAXXXX, WBXXXX, WFXXXX, WHXXXX, WIXXXX, WJXXXX, WKXXXX, WMXXXX, XAXXXX, XCXXXX, YBXXXX, YCXXXX, YDXXXX, YEXXXX

Category(s): Collaboration Sought > Licensing, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, Application > Consumer Products, ResearchProducts > Antibodies, Application > Research Materials, Application > Occupational Safety and Health, Application > Diagnostics

Sensitive Method for Detection and Quantification of Anthrax, Bordetella pertussis, Clostridium difficile, Clostridium botulinum and Other Pathogen-Derived Toxins in Human and Animal Plasma

CDC research scientists have developed a method to identify and quantify the activity of pathogenic bacterial adenylate cyclase toxins by liquid chromatography tandem mass spectrometry (LC-MS/MS). Bacterial protein toxins are among the most potent natural poisons known, causing paralysis, immune system collapse, hemorrhaging and death in some cases....

Published: 7/25/2024 | Inventor(s): Renato Lins, Zsuzsanna Kuklenyik, Conrad Quinn, John Barr, Anne Boyer

Keywords(s): AA5XXX, ADENYLATE, CDC Docket Import, CDC Docket Import CDC Prosecuting, CYCLASE, DA3XXX, DAXXXX, Detection, DXXXXX, ONDIEH-NCEH, VBXXXX, VJXXXX, WAXXXX, WBXXXX, WCXXXX, WIXXXX, WMXXXX, XCXXXX, XDXXXX, XHXXXX, XJXXXX, YBXXXX, YCXXXX, YDXXXX

Category(s): Collaboration Sought > Licensing, ResearchProducts > Computational models/software, Application > Software / Apps, TherapeuticArea > Infectious Disease, Application > Non-Medical Devices, Application > Therapeutics, Application > Vaccines, Application > Consumer Products, Application > Medical Devices, Application > Diagnostics, ResearchProducts > Research Equipment, Application > Research Materials, Application > Occupational Safety and Health

Novel Epitopes of Bacillus anthracis Lethal Factor for Development of Diagnostics and Therapeutics

CDC researchers have characterized epitopes of Bacillus anthracis Lethal Factor (LF), a critical component of the B. anthracis lethal toxin. These epitopes may allow for development of therapeutics for the treatment or prevention of B. anthracis infection. They may also allow screening for B. anthracis LF in a sample and development of a peptide anthrax...

Published: 7/25/2024 | Inventor(s): Dennis Bagarozzi, Anne Boyer, Conrad Quinn, Jason Goldstein

Keywords(s): Activiating, Activity, Anthracis, Anthrax, AnthraxToxins, Bacillus, Biodefense, biosecurity, bioterrorism, Bioterrorist, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DA5XXX, DAXXXX, DB3XXX, DB5XXX, DBXXXX, DC4XXX, DCXXXX, DXXXXX, Epitope, factor, INFECTIOUS, Lethal, MONITOR, MONITORING, Neutralize, Neutralizing, Region, REGULATING, SCREEN, screening, SERODIAGNOSIS, SERODIAGNOSTIC, Serologic, SEROLOGICAL, therapeutic, Therapeutic/Diagnostic, THERAPY, toxin, TOXIN-BINDING, Vaccine, VBXXXX, VETERINARY, Via, VJXXXX, VOXXXX, WAXXXX, WBXXXX, WFXXXX, WJXXXX, WKXXXX, WMXXXX, XAXXXX, XCXXXX, XHXXXX, YAXXXX, YBXXXX, Zoo, Zoonotic

Category(s): Collaboration Sought > Licensing, Application > Vaccines, Application > Occupational Safety and Health, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Therapeutics, ResearchProducts > Research Equipment, TherapeuticArea > Immunology, Application > Research Materials, ResearchProducts > Antibodies, Application > Diagnostics

Linear Epitopes of Anthrax Toxin Protective Antigen for Development of a Peptide Vaccine

Bacillus anthracis is a gram-positive, spore-forming bacteria that causes anthrax infection in humans. CDC inventors have identified epitope sequences of B. anthracis protective antigen (PA) that may be useful for development of peptide-based anthrax vaccines. This invention also relates to methods for determining whether post-vaccination protection...

Published: 7/25/2024 | Inventor(s): Conrad Quinn, Jan Pohl, Pavel Svoboda, Shannon Dalton, Jarad Schiffer, Stephen Soroka, Vera Semenova

Keywords(s): Anthrax, ANTIGEN, Bacillus, biosecurity, Bioterrism, Bio-terrorism, Bioterrorist, BioWarfare, CDC Docket Import, CDC Docket Import CDC Prosecuting, DC1XXX, DC4XXX, DCXXXX, Development, DXXXXX, Epitopes, LINEAR, OID-NCIRD-DBD, PA, Peptide, Protection, Protective, toxin, Vaccine

Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Infectious Disease