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Humanized Monoclonal Antibodies Efficient for Neutralization of Tick-Borne Encephalitis Virus (TBEV)

TBEV causes serious illnesses from meningitis to meningo-encephalitis, totaling 3,000 cases of hospitalization in Europe and between 5,000-10,000 cases in Russia reported every year. The Far Eastern hemorrhagic TBEV strains are associated with a mortality rate (between 1-2%), higher than other strains isolated in the Siberia or Western Europe. There...

Published: 7/25/2024 | Inventor(s): Alexander Pletnev, Ching-juh Lai, Robert Purcell

Keywords(s): antibodies, ANTIBODY, Binding/Neutralization, Chimpanzee, DA4BXX, DA4XXX, DAXXXX, DB4BXX, DB4XXX, DBXXXX, DDXXXX, DERIVED, DXXXXX, Efficient, ENCEPHALITIS, FAB, Fragments, HUMANIZED, monoclonal, TBEV, TICK-BORNE, virus

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Infectious Disease

Full-Length Infectious cDNA Clones of Tick Borne Flavivirus

The tick-borne encephalitis virus complex of flavivirus family includes tick-borne encephalitis (TBEV), Kyasanur forest disease, Langat, Louping ill, Negishi, Omsk hemorrhagic fever and Povassan viruses. These viruses are endemic throughout most of the Northern Hemisphere and except for Langat, cause human disease of varying severity that can have...

Published: 7/25/2024 | Inventor(s): Robert Chanock (Estate), Alexander Pletnev

Keywords(s): Borne, cDNA, CLONES, DC5BXX, DC5XXX, DCXXXX, DXXXXX, Flavivirus, FULL-LENGTH, Hemorrhagic fever, INFECTIOUS, Omsk hemorrhagic fever, Patent Category - Biotechnology, Q fever, SACGHS DNA Patent Initial Set, TICK, Tick-borne encephalitis, UAXXXX

Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare / Neglected Diseases

Antigenic Chimeric Tick-Borne Encephalitis Virus/Dengue Virus Type 4 Recombinant Viruses

The tick-borne encephalitis virus (TBEV) complex is a group of viruses that can cause severe neutrotropic disease and up to thirty percent (30%) mortality. While these viruses can be found in many parts of the world, the largest impact of the disease occurs in Europe and Russia, where approximately fourteen thousand (14,000) hospitalized TBEV cases...

Published: 7/25/2024 | Inventor(s): Brian Murphy, Amber Engel, Alexander Pletnev

Keywords(s): 4, ANTIGENIC, CANDIDATES, CAUSED, chimeric, Chromosome 7, monosomy, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, Deletion 7, Dengue (Flaviviridae), Development, Disease, DXXXXX, ENCEPHALITIS, Patent Category - Biotechnology, Prevention, recombinant, TBEV, TBEV/DEN4, TICK-BORNE, Tick-borne encephalitis, TYPE, Vaccine, virus, Virus/dengue, Viruses

Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease

A Full-Length Infectious cDNA Clone of Zika Virus from the 2015 Epidemic in Brazil as a Genetic Platform for Studies of Virus-Host Interactions and Vaccine Development

An arthropod-borne virus, Zika virus (ZIKV), has recently emerged as a major human pathogen. Associated with complications during perinatal development and Guillain-Barré syndrome in adults, ZIKV raises new challenges for understanding the molecular determinants of flavivirus pathogenesis. This underscores the necessity for the development of a reverse...

Published: 7/25/2024 | Inventor(s): Konstantin Tsetsarkin, Alexander Pletnev

Keywords(s): 2015, Brazil, cDNA, CLONE, DAXXXX, DBXXXX, DC5BXX, DC5XXX, DC6XXX, DCXXXX, DD1XXX, DDXXXX, Development, DXXXXX, Epidemic, FULL-LENGTH, Genetic, INFECTIOUS, INTERACTIONS, PLATFORM, STUDIES, Vaccine, virus, Virus-Host, Zika

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Vaccines, Application > Research Materials, Application > Diagnostics

Synergistic Internal Ribosomal Entry Site (IRES)—MicroRNA-Based Approach for Attenuation of Flaviviruses and Live Vaccine Development

Many members of the Flaviviridae family are emerging and reemerging human pathogens that have caused outbreaks of devastating and often fatal diseases and represent a serious public health problem on a global scale. There is no single attenuation strategy that exists which is sufficient to prepare a safe, efficacious and immunogenic live attenuated...

Published: 7/25/2024 | Inventor(s): Konstantin Tsetsarkin, Alexander Pletnev

Keywords(s): Approach, ATTENUATION, DC1XXX, DC5BXX, DC5XXX, DC6XXX, DCXXXX, DD1XXX, DDXXXX, Development, DEXXXX, DXXXXX, ENTRY, FLAVIVIRUSES, INTERNAL, Live, Pnd, RIBOSOME, Site/microRNA-based, Synergistic, Vaccine, Zika

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Research Materials, Application > Vaccines

Live Attenuated Vaccine to Prevent Disease Caused by West Nile Virus

West Nile virus (WNV) has recently emerged in the U.S. and is considered a significant emerging disease that has embedded itself over a considerable region of the U.S. WNV infections have been recorded in humans as well as in different animals. From 1999-2014, WNV killed 1,765 people in the U.S. and caused severe disease in more than 41,762 others....

Published: 7/25/2024 | Inventor(s): Robert Chanock (Estate), Joseph Putnak, Brian Murphy, Joseph Blaney, Stephen Whitehead, Alexander Pletnev

Keywords(s): Chimeras, DC5BXX, DC5XXX, DCXXXX, DENGUE, Dengue (Flaviviridae), DXXXXX, Live, Nile, Vaccine, virus, VLXXXX, VOXXXX, WAXXXX, WBXXXX, West, WEST NILE VIRUS, WMXXXX, WNXXXX, XKXXXX, YCXXXX, YDXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines, Application > Consumer Products, Application > Diagnostics

Live Attenuated Zika Virus Vaccine

This application claims live attenuated Zika viruses and vaccines, attenuated chimeric Zika viruses and vaccines, and multivalent immunogenic compositions comprising Zika vaccines and vaccines for other flaviviruses. The chimeric Zika viruses claimed include a first nucleotide sequence encoding at least one structural protein from a Zika virus (ZIKV),...

Published: 7/25/2024 | Inventor(s): Sara Woodson, Anna Durbin, Alexander Pletnev, Konstantin Tsetsarkin, Stephen Whitehead

Keywords(s): Attenuated, CANDIDATES, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, DXXXXX, Live, Vaccine, virus, Zika

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Vaccines, Application > Research Materials, TherapeuticArea > Infectious Disease