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Compositions and Methods for Improved Lyme Disease Diagnosis

This CDC-developed technology entails novel compositions and methods related to the diagnosis of Lyme disease. Lyme disease, caused by the Borrelia burgdorferi bacterium, is the most common tick-borne infectious disease in the US and Europe. Diagnosis of Lyme disease is particularly challenging as symptoms often appear long after exposure. At present,...

Published: 7/25/2024 | Inventor(s): Theresa Russell, Barbara Johnson

Keywords(s): BACTERIA, BORRELIA BURGDORFERI, BORRELLIA, BURGDORFERI, CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DA3XXX, DAXXXX, diagnostic, Diagnostic assay, diagnostic in vitro, Disease, DXXXXX, ivd, LYME, Methods, Relating, TICK, TICK-BORNE, TICKS, Vector-borne, Vector-borne diseases, VETERINARY, VJXXXX, VOXXXX, WBXXXX, WCXXXX, WDXXXX, WFXXXX, WIXXXX, WMXXXX, XCXXXX, YBXXXX, Zoonotic

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Occupational Safety and Health, Application > Consumer Products, TherapeuticArea > Infectious Disease

Diagnostics, Vaccines, and Delivery-Vehicles Related to Novel Phlebovirus

This CDC invention relates to primers and probes that specifically hybridize with Heartland virus (HRTLDV), a unique member of the genus Phlebovirus. It further relates to polyclonal antibodies specific for HRTLDV proteins. Serological detection assays using HRTLDV nucleic acid molecules, proteins, probes, primers, and antibodies are provided. Importantly,...

Published: 7/25/2024 | Inventor(s): Stuart Nichol, William Nicholson, Cynthia Goldsmith, Aubree Kelly, Laura McMullan

Keywords(s): AC4XXX, ACXXXX, ANTIBODY, ANTIGEN, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DA4BXX, DA4XXX, DAXXXX, DC1XXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, Delivery, delivery system, DEVELOPED, diagnostic, DXXXXX, GB2CXX, GB2XXX, GBXXXX, GCXXXX, GENE THERAPY, gene transfer, GXXXXX, heartland, heartland virus, Hospitalized, Identification, ISOLATES, Isolation, Methods, Missouri, Novel, PATHOGENIC, PHLEBOVIRUS, PLATFORM, Platforms, sequence, therapeutic, therapeutic candidates, THEREOF, TICK, TICK-BORNE, TICKS, TWO, Vaccine, VACCINE VECTORS, Vector, Vector-based, Vector-borne, Vector-borne diseases, VETERINARY, VETERINARY vaccine, viral, virus, VLXXXX, VOXXXX, WBXXXX, WDXXXX, WFXXXX, WIXXXX, WJXXXX, XAXXXX, XCXXXX, XHXXXX, YAXXXX, YBXXXX, Zoo

Category(s): Collaboration Sought > Licensing, ResearchProducts > Antibodies, ResearchProducts > Research Equipment, Application > Research Materials, TherapeuticArea > Immunology, Application > Diagnostics, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Occupational Safety and Health, Application > Consumer Products

Novel Targets to Prevent Borrelia burgdorferi Infection and Lyme Disease

B. burgdorferi-infected ticks can cause Lyme disease in mammalian hosts. This technology relates to the use of B. burgdorferi outer surface proteins (BBA64 and BBA66) as Lyme disease vaccine candidates. In vivo animal studies demonstrate these outer surface proteins inhibit tick-to-host B. burgdorferi transmission. Presently, there is no vaccine approved...

Published: 4/8/2024 | Inventor(s): Robert Gilmore

Keywords(s): BBA66, BORRELIA, BURGDORFERI, CDC Docket Import, CDC Docket Import CDC Prosecuting, COMPONENT, DA3XXX, DAXXXX, DB3XXX, DBXXXX, DC4XXX, DXXXXX, Gene, Infectivity, MAMMALIAN, Necessary, PATHOGEN, TICK, TRANSMISSION, Vector, Via

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines, Application > Diagnostics

Full-Length Infectious cDNA Clones of Tick Borne Flavivirus

The tick-borne encephalitis virus complex of flavivirus family includes tick-borne encephalitis (TBEV), Kyasanur forest disease, Langat, Louping ill, Negishi, Omsk hemorrhagic fever and Povassan viruses. These viruses are endemic throughout most of the Northern Hemisphere and except for Langat, cause human disease of varying severity that can have...

Published: 7/25/2024 | Inventor(s): Robert Chanock (Estate), Alexander Pletnev

Keywords(s): Borne, cDNA, CLONES, DC5BXX, DC5XXX, DCXXXX, DXXXXX, Flavivirus, FULL-LENGTH, Hemorrhagic fever, INFECTIOUS, Omsk hemorrhagic fever, Patent Category - Biotechnology, Q fever, SACGHS DNA Patent Initial Set, TICK, Tick-borne encephalitis, UAXXXX

Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare / Neglected Diseases