Search Results - murine

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Abstract: Tumor cell lines are important tools for the study of cancer. However, most tumor cell lines available today do not mimic physiological tumor development, progression, and host immune responses. Autochthonous tumors include spontaneously occurring tumors and chemical, viral, or physical carcinogen-induced tumors. They are considered to model...

Published: 4/8/2024 | Inventor(s): Jeffrey Schlom, Scott Abrams

Keywords(s): AT-3, Autochthonous Tumor, Autologous Tumor Cell Line, BREAST CANCER, In Vitro Animal Model, Mouse, Murine, Schlom

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Research Materials

Transgenic Mouse Model of Human Basal Triple Negative Breast Cancer

Abstract: The NCI Laboratory of Cancer Biology and Genetics seeks parties interested in collaborative research to further develop this mouse model of triple-negative breast cancer (TNBC) to study cancer biology and for preclinical testing. As a Research Tool, patent protection is not being pursued for this technology; more information to access this...

Published: 5/23/2024 | Inventor(s): Jeffrey Green

Keywords(s): Mouse, Murine, PROSTATE, triple-negative breast cancer

Category(s): TherapeuticArea > Oncology, Application > Research Materials, Collaboration Sought > Licensing

Murine Model of Niemann-Pick Disease Type C

This technology includes a transgenic mouse model of Niemann-Pick Disease Type C (NPC), which is a rare neurodegenerative disorder, characterized by intracellular accumulation of cholesterol and gangliosides. The mouse strain, Tg(Npcl), expresses wild-type NPC1 gene under the control of the prion promoter. When combined with the NPC deficient mouse...

Published: 7/25/2024 | Inventor(s): Stacie Loftus, William ("Bill") Pavan

Keywords(s): C, Disease, Listed LPM Maddox as of 4/15/2015, Model, Murine, NIEMANN-PICK, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RXXXXX, VEXXXX, VHXXXX, VNXXXX, VPXXXX, WIXXXX, WKXXXX, XEXXXX

Category(s): TherapeuticArea > Infectious Disease, TherapeuticArea > Psychiatry/Mental Health, Application > Therapeutics, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, TherapeuticArea > Neurology, Application > Research Materials, TherapeuticArea > Ophthalmology

Murine Models of an Autoinflammatory Disease, Familial Mediterranean Fever (FMF), to Study the Pathophysiology of Inherited Disorders of Inflammation and Evaluate New Therapies

This technology includes mouse models (heterozygous for the knock-in (KI) and homozygous for the knock-out (KO)) to be used as research reagents and to study molecular mechanisms and potential therapies for Familial Mediterranean fever (FMF). FMF is the prototype of a group of inherited disorders characterized by recurring, spontaneous episodes of fever...

Published: 7/25/2024 | Inventor(s): Jae Chae, Daniel ("Dan") Kastner

Keywords(s): Autoinfla~-~atory, Autoinflamatory, Disease, FAMILIAL, FEVER, FMF, MEDITERRANEAN, Models, Murine, VPXXXX, WIXXXX, XEXXXX

Category(s): Application > Therapeutics, Application > Research Materials, TherapeuticArea > Oncology, TherapeuticArea > Dental, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, TherapeuticArea > Endocrinology, TherapeuticArea > Infectious Disease

Mononegavirales Vectors Expressing Chimeric Antigens

Human respiratory syncytial virus (RSV) continues to be the leading viral cause of severe acute lower respiratory tract disease in infants and children worldwide, and also is an important cause of morbidity and mortality in the elderly. A licensed vaccine or antiviral drug suitable for routine use remains unavailable. This invention relates to the use...

Published: 7/25/2024 | Inventor(s): Linda Brock, Ursula Buchholz, Peter Collins, Shirin Munir

Keywords(s): Added, Attenuated, DA4BXX, DA4XXX, DC5BXX, DC5XXX, DCXXXX, DD1XXX, DDXXXX, DEXXXX, DXXXXX, Expressing, F, Fusion, Gene, Highly, Human, Immunogenic, Macaques, MPV, Murine, PNEUMONIA, Protein, respiratory, RHESUS, RSV, Syncytial, virus

Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease

Mononegavirales Vectors expressing Chimeric Antigens

Human respiratory syncytial virus (RSV) continues to be the leading viral cause of severe acute lower respiratory tract disease in infants and children worldwide. A licensed vaccine or antiviral drug suitable for routine use remains unavailable. This invention relates to the use of murine pneumonia virus (MPV), a virus to which humans normally are not...

Published: 7/25/2024 | Inventor(s): Peter Collins, Ursula Buchholz, Linda Brock, Shirin Munir

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, Application > Vaccines, TherapeuticArea > Infectious Disease

Hybridoma Cell Line 715 Producing Monoclonal Antibody Specific for Murine Leukemia Virus gp70

Hybridoma cell line 715 expresses monoclonal antibody specific for Moloney murine leukemia virus (MuLV) gp70. Details may be found under NIH AIDS Reagent Program Catalog Number 1278: https://www.beiresources.org/Catalog/BEICellLinesUninfected/ARP-1278.aspx .

Published: 7/25/2024 | Inventor(s): Bruce Chesebro

Keywords(s): 715, Cell, DDXXXX, Detect, Hybridoma, Leukemia, Line, Listed LPM Ano as of 4/15/2015, Mab, moloney, Murine, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RM, virus, VLXXXX, WIXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Research Materials

Hybridoma Cell Line 500 Producing Monoclonal Antibody Specific for Murine Leukemia Virus gp80

Hybridoma cell line 500 expresses monoclonal antibody specific for Moloney murine leukemia virus (MuLV) gp80. Details may be found under NIH AIDS Reagent Program Catalog Number 1277: https://www.beiresources.org/Catalog/BEICellLinesUninfected/ARP-1277.aspx .

Published: 7/25/2024 | Inventor(s): Bruce Chesebro

Keywords(s): 500, Cell, DDXXXX, Detect, Hybridoma, Leukemia, Line, Listed LPM Ano as of 4/15/2015, Mab, moloney, Murine, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RM, virus, VLXXXX, WIXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Research Materials

Hybridoma Cell Line 273 Producing Monoclonal Antibody Specific for Murine Leukemia Virus gp70

Hybridoma cell line 273 expresses monoclonal antibody specific for murine leukemia virus (MuLV) gp70. Details may be found under NIH AIDS Reagent Program Catalog Number 1279: https://www.beiresources.org/Catalog/BEICellLinesUninfected/ARP-1279.aspx .

Published: 7/25/2024 | Inventor(s): Bruce Chesebro

Keywords(s): 273, Cell, DDXXXX, Detect, Hybridoma, Leukemia, Line, Listed LPM Ano as of 4/15/2015, Mab, moloney, Murine, NIH ARP, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RM, virus, VLXXXX, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Infectious Disease

TL1A Transgenic Mice for the Study of Inflammatory Bowel Disease (IBD) and Allergic-Type Immune Responses

TL1A is a TNF family cytokine that co-stimulates T-cell proliferation and cytokine production through its interactions with the TNF family receptor DR3. TL1A-DR3 interactions have been shown to be important for the development of autoimmune inflammatory diseases, including inflammatory bowel disease (IBD). In order to probe the role of TL1A-DR3 interactions...

Published: 7/30/2024 | Inventor(s): Francoise Meylan, Richard Siegel

Keywords(s): Allergic-type, Autoimmune, BOWEL, DR3, IBD, IDXXXX, IL-13, IMMUNE, INFLAMMATORY, inflammatory bowel disease, IXXXXX, Mouse, Murine, TL1A, TL1A/DR3, TLlA-transgenic, tnf, TNFSF15

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Application > Research Materials, Application > Diagnostics

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