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Novel Cancer Immunotherapy: A T Cell Receptor That Specifically Recognizes Common KRAS Mutations

Abstract: Several malignancies associated with a poor prognosis such as lung, pancreatic and colorectal cancers frequently harbor constitutively active KRAS mutants, which play a pivotal role in oncogenesis. Currently, there are no potentially curative treatments against most mutant KRAS harboring cancers once they become metastatic and unresectable. ...

Published: 4/22/2025 | Inventor(s): Qiong Wang, James Yang, Zhiya Yu

Keywords(s): Colorectal, Immunotherapy, KRAS, LUNG, oncogenesis, PANCREAS, PROSTATE, T cell, TCR

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics

Transgenic Mouse Model of Human Basal Triple Negative Breast Cancer

Abstract: The NCI Laboratory of Cancer Biology and Genetics seeks parties interested in collaborative research to further develop this mouse model of triple-negative breast cancer (TNBC) to study cancer biology and for preclinical testing. As a Research Tool, patent protection is not being pursued for this technology; more information to access this...

Published: 4/22/2025 | Inventor(s): Jeffrey Green

Keywords(s): Mouse, Murine, PROSTATE, triple-negative breast cancer

Category(s): TherapeuticArea > Oncology, Application > Research Materials, Collaboration Sought > Licensing