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Real-Time PCR Assay for HIV-1 Subtype Diagnosis and Global Surveillance of Drug Resistance
Case ID:
TAB-3384
Web Published:
12/6/2022
Description:
CDC researchers have developed a patented set of RT-PCR and sequencing primers based on HIV-1 group M sequences. Evaluation of the primers using samples collected around the world demonstrated broad detection capacity for multiple HIV-1 group subtypes and predominant circulating recombinant forms. Commercially available HIV-1 drug resistance (HIVDR) genotyping assays are expensive and have limited ability to detect non-B subtypes. This optimized assay is broadly sensitive in genotyping HIV-1 group M viral strains and more sensitive than other assays in detecting mixed viral populations. This technology can be used in resource-limited settings where HIVDR surveillance is recommended to minimize the development and transmission of HIVDR.
Utility for HIV-1 sub-typing detection, evaluation of anti-HIV therapeutic efficacy, and HIV drug resistance (HIVDR) surveillance and monitoring
Rapid, accurate, and cost-effective technology easily adapted as a kit
Patent Information:
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Direct Link:
https://nih.technologypublisher.com/tech/Real-Time_PCR_Assay_for_HIV-1_Subtyp e_Diagnosis_and_Global_Surveillance_of_Drug_Resistance
Category(s):
Collaboration
Licensing
Infectious Disease
Diagnostics
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For Information, Contact:
Jeremiah Mitzelfelt
NIH Technology Transfer
301-443-8518
jeremiah.mitzelfelt@nih.gov
Inventors:
Joshua Devos
Nicholas Wagar
Zhiyong Zhou
Chunfu Yang
Keywords:
AIDS
assay
blood-borne
CDC Docket Import
CDC Docket Import CDC Prosecuting
CGH-DGHA
DA4AXX
DA4XXX
DAXXXX
DEVELOPING
Diagnosis
diagnostic
DRUG
drug resistance
drug resistant
DXXXXX
EMERGING
EPIDEMIOLOGIC
Genotype
Genotyping
Global
HIV
HIV-1
Listed LPM Houze as of 4/15/2015
PCR
Post LPM Assignment Set 20150420
Pre LPM working set 20150418
Resistance
RESISTANT
RT-PCR
Surveillance
therapeutic
tropical
viral
virus
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