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Real-Time PCR Assay for HIV-1 Subtype Diagnosis and Global Surveillance of Drug Resistance

CDC researchers have developed a patented set of RT-PCR and sequencing primers based on HIV-1 group M sequences. Evaluation of the primers using samples collected around the world demonstrated broad detection capacity for multiple HIV-1 group subtypes and predominant circulating recombinant forms. Commercially available HIV-1 drug resistance (HIVDR)...

Published: 7/25/2024 | Inventor(s): Joshua Devos, Nicholas Wagar, Zhiyong Zhou, Chunfu Yang

Keywords(s): AIDS, assay, blood-borne, CDC Docket Import, CDC Docket Import CDC Prosecuting, CGH-DGHA, DA4AXX, DA4XXX, DAXXXX, DEVELOPING, Diagnosis, diagnostic, DRUG, drug resistance, drug resistant, DXXXXX, EMERGING, EPIDEMIOLOGIC, Genotype, Genotyping, Global, HIV, HIV-1, Listed LPM Houze as of 4/15/2015, PCR, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Resistance, RESISTANT, RT-PCR, Surveillance, therapeutic, tropical, viral, virus

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Diagnostics

Probe Set Global Optimization

Available for licensing and commercial development are methods to optimize sequence-based assays such as microarrays, multiplexed PCR or multiplexed antibody methods. This computational method uses numerical optimization to identify an optimal probe set to be used in an assay for the measurement of a specified set of targets. The method incorporates...

Published: 4/8/2024 | Inventor(s): Kevin Brown, Eric Billings

Keywords(s): AA5XXX, AAXXXX, AC4XXX, ACXXXX, assay, AXXXXX, Bacterial, CA1AXX, CA1XXX, CAXXXX, computer methods, CXXXXX, DAXXXX, DXXXXX, Global, IAXXXX, IXXXXX, Nucleotide, OPTIMIZATION, PATHOGEN, Probe, probe set, Protein, SELECTION, Sequences, splice variants, VIRAL DIAGNOSTIC

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Oncology