Search Results - nitric+oxide

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Abstract: The National Cancer Institute's Laboratory of Pathology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize therapeutics targeting vasodialation. Nitric oxide (NO) plays an important role as a major intrinsic vasodilator, and increases blood flow...

Published: 4/8/2024 | Inventor(s): Jeff Isenberg, David Roberts, William Frazier

Keywords(s): CD47, ISCHEMIA, nitric oxide, NO, THROMBOSPONDIN

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics

PARP Inhibitor and NO-Donor Dual Prodrugs as Anticancer Agents

Abstract: Poly-ADP ribose polymerase-1 (PARP-1) is a critical enzyme involved in DNA repair. The inhibition of PARP has emerged as a promising strategy in cancer therapy. Numerous PARP inhibitors have been developed and advanced into clinical trials, both for use as single agents in specific patient populations and as combination therapies with various...

Published: 5/22/2024 | Inventor(s): Anna Maciag, Joseph Saavedra, Larry Keefer, Xinhua Ji, Vandana Kumari

Keywords(s): nitric oxide, PARP, poly-ADP-ribose polymerase, prodrug

Category(s): TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing

Nitric Oxide-Releasing Polymers for Wound Healing

Abstract: A number of factors can play a detrimental role in the process of wound healing such as poor nutritional status, smoking, various drugs, cancer, and diabetes. Wound healing impairment is a challenging clinical problem with no efficacious treatments currently available. Nitric oxide (NO) has been shown to play a role in the process of wound...

Published: 5/22/2024 | Inventor(s): Joseph Hrabie, Larry Keefer

Keywords(s): Bioabsorption, Dermatological conditions, nitric oxide, Polyvinyl Pyrrolidone (povidone), Wound healing

Category(s): TherapeuticArea > Immunology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Dermatology, Application > Therapeutics

Nitric Oxide Based Therapeutics for the Treatment of Lung Cancer

Abstract: Nitric oxide (NO) has a broad spectrum of actions in physiological and pathological processes. NO-donor drugs have shown therapeutic effect in several cancer types by inducing apoptosis but the concentrations required have suggested limited clinical applicability. For cancers such as non-small cell lung cancer where most therapies are not...

Published: 5/22/2024 | Inventor(s): Anna Maciag, Harinath Chakrapani, Joseph Saavedra, Lucy Anderson, Larry Keefer

Keywords(s): Diazeniumdiolate, nitric oxide, NO, prodrug, Reactive Oxygen Species, ROS

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Therapeutics

NSAIDs that Assist the Treatment of Human Diseases

Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) have long been used to treat a variety of inflammatory conditions. Many of these conditions, such as cancer or arthritis, require long term use of the NSAIDs due to the chronic nature of the disease. However, the NSAIDs in current use have toxicities associated with their long-term use that...

Published: 4/8/2024 | Inventor(s): David Wink, Wilmarie Flores-Santana, S. Bruce King, Murali Cherukuri, James Mitchell

Keywords(s): David Wink, HNO, Inflammation, nitric oxide, NITROXYL, non-steroidal anti-inflammatory drugs, NSAID

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics, TherapeuticArea > Immunology

Topical Sodium Nitrate Ointment for Sickle Cell Disease

Abstract: Chronic leg ulcers are a debilitating vasculopathic complication for some patients with sickle cell disease (SCD). Prevalence of leg ulcers varies based on age and geographic location; about 5-10% of all SCD patients may suffer leg ulcers. These leg ulcers are painful, result in infections, hospitalization, disability, and negatively impact...

Published: 4/8/2024 | Inventor(s): Haksong Jin, George Grimes, Deborah Sperling, Gopal Potti, Caterina Minniti-Crouch, Gregory Kato

Keywords(s): Blood Disorder, CREAM, Haksong, nitric oxide, Ointment, SCD, sickle cell disease, Sodium Nitrate, TOPICAL, Topical Therapeutic, Vascular Ulcers, Wound healing

Category(s): TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Cardiology, Collaboration Sought > Licensing

Methods for Amelioration and Treatment of Pathogen-associated Inflammatory Response

This CDC invention provides methods for preventing or treating inflammatory response-linked, infection induced pathologies, which are mediated by endogenous substance P. Substance P is a naturally-occurring and major pro-inflammatory neuromediator or neuromodulator, and elevated levels of substance P have been implicated in numerous inflammation-associated...

Published: 7/25/2024 | Inventor(s): Larry Anderson, Deborah Moore, Ralph Tripp

Keywords(s): bronchoilitis, CAUSED, CDC Docket Import, CDC Docket Import CDC Prosecuting, DB3XXX, DB4XXX, DBXXXX, DISEASES, DXXXXX, IB3XXX, Infection, Inflammation, INFLAMMATORY, Methods, nitric oxide, OID-NCIRD-DVD, P, Pain, pain control, Prevention, Pulmonary, RESPONSE, RSV, RSV virus, SUBSTANCE, SUBSTANCE p, treatment, treatment methods, vasodilation, VASODILATOR, VAXXXX, VBXXXX, VDXXXX, VEXXXX, VJXXXX, VKXXXX, VLXXXX, VMXXXX, VOXXXX, VPXXXX, WAXXXX, WIXXXX, WJXXXX, WKXXXX, WMXXXX, XAXXXX, XCXXXX, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Ophthalmology, TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, TherapeuticArea > Oncology, Application > Consumer Products, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, Application > Vaccines, ResearchProducts > Antibodies, TherapeuticArea > Immunology, TherapeuticArea > Neurology, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Geriatrics