Search Results - diazeniumdiolate

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Nitric Oxide-Releasing Polysaccharide Materials

Abstract: Diazeniumdiolates comprise a diverse class of NO-releasing compounds and materials that are known to exhibit sufficient stability to be useful as therapeutics. Diazeniumdiolated compounds have been attached to polymers, substrates, and medical devices for the treatment and management of a variety of diseases including cancer, inflammation,...

Published: 5/22/2024 | Inventor(s): Joseph Hrabie, Larry Keefer

Keywords(s): bandages, biofilm dispersal, Cellulose, Diazeniumdiolate, Nitric Oxide (NO), POLYSACCHARIDE, Wound healing

Category(s): Collaboration Sought > Materials Available, TherapeuticArea > Immunology, Collaboration Sought > Licensing, Application > Therapeutics

Nitric Oxide Based Therapeutics for the Treatment of Lung Cancer

Abstract: Nitric oxide (NO) has a broad spectrum of actions in physiological and pathological processes. NO-donor drugs have shown therapeutic effect in several cancer types by inducing apoptosis but the concentrations required have suggested limited clinical applicability. For cancers such as non-small cell lung cancer where most therapies are not...

Published: 5/22/2024 | Inventor(s): Anna Maciag, Harinath Chakrapani, Joseph Saavedra, Lucy Anderson, Larry Keefer

Keywords(s): Diazeniumdiolate, nitric oxide, NO, prodrug, Reactive Oxygen Species, ROS

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Therapeutics