Search Results - wound+healing

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Nitric Oxide-Releasing Polysaccharide Materials

Abstract: Diazeniumdiolates comprise a diverse class of NO-releasing compounds and materials that are known to exhibit sufficient stability to be useful as therapeutics. Diazeniumdiolated compounds have been attached to polymers, substrates, and medical devices for the treatment and management of a variety of diseases including cancer, inflammation,...

Published: 5/22/2024 | Inventor(s): Joseph Hrabie, Larry Keefer

Keywords(s): bandages, biofilm dispersal, Cellulose, Diazeniumdiolate, Nitric Oxide (NO), POLYSACCHARIDE, Wound healing

Category(s): Collaboration Sought > Materials Available, TherapeuticArea > Immunology, Collaboration Sought > Licensing, Application > Therapeutics

Topical Antibiotic for Faster Wound Healing

Abstract: Currently available topical antibiotic formulations effectively eliminate bacteria at a wound site. Eliminating bacteria in the wound also eliminates the molecular signals present in bacterial DNA that stimulate the immune system's wound healing processes. Without these signals, the rate of wound healing is diminished. The present technology...

Published: 5/22/2024 | Inventor(s): Dennis Klinman, Hiroyasu Ito

Keywords(s): CpG motifs, Immunostimulation, ODN., Oigodeoxynucleotides, TLR7, TLR9, Wound healing

Category(s): TherapeuticArea > Dermatology, Collaboration Sought > Licensing, Application > Therapeutics

Nitric Oxide-Releasing Polymers for Wound Healing

Abstract: A number of factors can play a detrimental role in the process of wound healing such as poor nutritional status, smoking, various drugs, cancer, and diabetes. Wound healing impairment is a challenging clinical problem with no efficacious treatments currently available. Nitric oxide (NO) has been shown to play a role in the process of wound...

Published: 5/22/2024 | Inventor(s): Joseph Hrabie, Larry Keefer

Keywords(s): Bioabsorption, Dermatological conditions, nitric oxide, Polyvinyl Pyrrolidone (povidone), Wound healing

Category(s): TherapeuticArea > Immunology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Dermatology, Application > Therapeutics

Topical Sodium Nitrate Ointment for Sickle Cell Disease

Abstract: Chronic leg ulcers are a debilitating vasculopathic complication for some patients with sickle cell disease (SCD). Prevalence of leg ulcers varies based on age and geographic location; about 5-10% of all SCD patients may suffer leg ulcers. These leg ulcers are painful, result in infections, hospitalization, disability, and negatively impact...

Published: 4/8/2024 | Inventor(s): Haksong Jin, George Grimes, Deborah Sperling, Gopal Potti, Caterina Minniti-Crouch, Gregory Kato

Keywords(s): Blood Disorder, CREAM, Haksong, nitric oxide, Ointment, SCD, sickle cell disease, Sodium Nitrate, TOPICAL, Topical Therapeutic, Vascular Ulcers, Wound healing

Category(s): TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Cardiology, Collaboration Sought > Licensing