Search Results - larry+keefer

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Nitric Oxide-Releasing Polysaccharide Materials

Abstract: Diazeniumdiolates comprise a diverse class of NO-releasing compounds and materials that are known to exhibit sufficient stability to be useful as therapeutics. Diazeniumdiolated compounds have been attached to polymers, substrates, and medical devices for the treatment and management of a variety of diseases including cancer, inflammation,...

Published: 5/22/2024 | Inventor(s): Joseph Hrabie, Larry Keefer

Keywords(s): bandages, biofilm dispersal, Cellulose, Diazeniumdiolate, Nitric Oxide (NO), POLYSACCHARIDE, Wound healing

Category(s): Collaboration Sought > Materials Available, TherapeuticArea > Immunology, Collaboration Sought > Licensing, Application > Therapeutics

PARP Inhibitor and NO-Donor Dual Prodrugs as Anticancer Agents

Abstract: Poly-ADP ribose polymerase-1 (PARP-1) is a critical enzyme involved in DNA repair. The inhibition of PARP has emerged as a promising strategy in cancer therapy. Numerous PARP inhibitors have been developed and advanced into clinical trials, both for use as single agents in specific patient populations and as combination therapies with various...

Published: 5/22/2024 | Inventor(s): Anna Maciag, Joseph Saavedra, Larry Keefer, Xinhua Ji, Vandana Kumari

Keywords(s): nitric oxide, PARP, poly-ADP-ribose polymerase, prodrug

Category(s): TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing

Nitric Oxide-Releasing Polymers for Wound Healing

Abstract: A number of factors can play a detrimental role in the process of wound healing such as poor nutritional status, smoking, various drugs, cancer, and diabetes. Wound healing impairment is a challenging clinical problem with no efficacious treatments currently available. Nitric oxide (NO) has been shown to play a role in the process of wound...

Published: 5/22/2024 | Inventor(s): Joseph Hrabie, Larry Keefer

Keywords(s): Bioabsorption, Dermatological conditions, nitric oxide, Polyvinyl Pyrrolidone (povidone), Wound healing

Category(s): TherapeuticArea > Immunology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Dermatology, Application > Therapeutics

Nitric Oxide Based Therapeutics for the Treatment of Lung Cancer

Abstract: Nitric oxide (NO) has a broad spectrum of actions in physiological and pathological processes. NO-donor drugs have shown therapeutic effect in several cancer types by inducing apoptosis but the concentrations required have suggested limited clinical applicability. For cancers such as non-small cell lung cancer where most therapies are not...

Published: 5/22/2024 | Inventor(s): Anna Maciag, Harinath Chakrapani, Joseph Saavedra, Lucy Anderson, Larry Keefer

Keywords(s): Diazeniumdiolate, nitric oxide, NO, prodrug, Reactive Oxygen Species, ROS

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Therapeutics