Search Results - poly-adp-ribose+polymerase

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PARP Inhibitor and NO-Donor Dual Prodrugs as Anticancer Agents

Abstract: Poly-ADP ribose polymerase-1 (PARP-1) is a critical enzyme involved in DNA repair. The inhibition of PARP has emerged as a promising strategy in cancer therapy. Numerous PARP inhibitors have been developed and advanced into clinical trials, both for use as single agents in specific patient populations and as combination therapies with various...

Published: 5/22/2024 | Inventor(s): Anna Maciag, Joseph Saavedra, Larry Keefer, Xinhua Ji, Vandana Kumari

Keywords(s): nitric oxide, PARP, poly-ADP-ribose polymerase, prodrug

Category(s): TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing